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LINC00305 long intergenic non-protein coding RNA 305 [ Homo sapiens (human) ]

Gene ID: 221241, updated on 27-Jan-2024

Summary

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Official Symbol
LINC00305provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 305provided by HGNC
Primary source
HGNC:HGNC:28597
See related
Ensembl:ENSG00000179676 MIM:617489; AllianceGenome:HGNC:28597
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT1235; C18orf20; NCRNA00305
Summary
Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 1.5) See more
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Genomic context

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Location:
18q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (64080009..64149026, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (64285107..64354119, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61747243..61816260, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9532 Neighboring gene Sharpr-MPRA regulatory region 9998 Neighboring gene serpin family B member 8 Neighboring gene ribosomal protein L12 pseudogene 39 Neighboring gene NANOG hESC enhancer GRCh37_chr18:61777924-61778425 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:61783938-61784528 Neighboring gene long intergenic non-protein coding RNA 1924 Neighboring gene uncharacterized LOC124904357 Neighboring gene long intergenic non-protein coding RNA 1538

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis. Wahba AS, et al. Br J Biomed Sci, 2020 Jul. PMID 32188348
  2. Long intergenic noncoding RNA 00305 sponges miR-136 to regulate the hypoxia induced apoptosis of vascular endothelial cells. Zhang BY, et al. Biomed Pharmacother, 2017 Oct. PMID 28763747
  3. Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes. Zhang DD, et al. Sci Rep, 2017 Apr 10. PMID 28393844, Free PMC Article
  4. RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. Chibi M, et al. J Mol Biol, 2008 Dec 26. PMID 18851979
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis.
    Title: Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis.
  2. LINC00305 promotes monocyte inflammation by facilitating LIMR and AHRR cooperation and the AHRR activation.
    Title: Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Clone Names

  • MGC39571

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027245.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021607
    Related
    ENST00000323355.3

  2. NR_190189.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021607

  3. NR_190190.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021607

  4. NR_190191.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021607

  5. NR_190192.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021607

  6. NR_190193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021607

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    64080009..64149026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    64285107..64354119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152728.1: Suppressed sequence

    Description
    NM_152728.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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