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Gfus GDP-L-fucose synthase [ Mus musculus (house mouse) ]

Gene ID: 22122, updated on 14-Nov-2024

Summary

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Official Symbol
Gfusprovided by MGI
Official Full Name
GDP-L-fucose synthaseprovided by MGI
Primary source
MGI:MGI:98857
See related
Ensembl:ENSMUSG00000022570 AllianceGenome:MGI:98857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FX; Tsta3; Tstap35b
Summary
Enables GDP-L-fucose synthase activity and isomerase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process. Acts upstream of or within T cell mediated cytotoxicity. Is active in cytosol. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 74.6), large intestine adult (RPKM 59.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gfus in Genome Data Viewer
Location:
15 D3; 15 35.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75796532..75801613, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75924669..75929821, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene zinc finger protein 623 Neighboring gene STARR-seq mESC enhancer starr_39034 Neighboring gene predicted gene, 53898

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Strain-specific modification of lethality in fucose-deficient mice. Becker DJ, et al. Mamm Genome, 2003 Feb. PMID 12584608
  2. Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. Wang Y, et al. Gastroenterology, 2017 Jan. PMID 27639802, Free PMC Article
  3. Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. Smith PL, et al. J Cell Biol, 2002 Aug 19. PMID 12186857, Free PMC Article
  4. An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3. Kizuka Y, et al. Cell Chem Biol, 2017 Dec 21. PMID 29033318
  5. Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele. Szikora JP, et al. EMBO J, 1990 Apr. PMID 2108859, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fucosylation-modified Notch receptor may represent a novel extrinsic regulator for hematopoietic stem cells (HSC) engraftment and HSC niche maintenance.
    Title: Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC113801

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-L-fucose synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-L-fucose synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-L-fucose synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GDP-L-fucose synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP-mannose 3,5-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' GDP-L-fucose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GDP-L-fucose synthase
Names
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
GDP-L-fucose synthetase
GDP-fucose synthase
protein FX
red cell NADP(H)-binding protein
tissue specific transplantation antigen P35B
transplantation antigen P35B
tum-P35B antigen
NP_001343934.1
NP_001398744.1
NP_001398745.1
NP_112478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357005.2 → NP_001343934.1  GDP-L-fucose synthase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27555.1
    UniProtKB/Swiss-Prot
    P23591
    UniProtKB/TrEMBL
    A0A2R8VHD0, Q5HZI6
    Related
    ENSMUSP00000155139.2, ENSMUST00000229641.2
    Conserved Domains (1) summary
    cd05239
    Location:9 → 312
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

  2. NM_001411815.1 → NP_001398744.1  GDP-L-fucose synthase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116520
    UniProtKB/TrEMBL
    A0A2R8VI39

  3. NM_001411816.1 → NP_001398745.1  GDP-L-fucose synthase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116520
    UniProtKB/TrEMBL
    A0A2R8VI39
    Related
    ENSMUSP00000155711.2, ENSMUST00000229951.2

  4. NM_031201.2 → NP_112478.1  GDP-L-fucose synthase isoform 1

    See identical proteins and their annotated locations for NP_112478.1

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27555.1
    UniProtKB/Swiss-Prot
    P23591
    UniProtKB/TrEMBL
    A0A2R8VHD0, Q5HZI6
    Related
    ENSMUSP00000023231.6, ENSMUST00000023231.7
    Conserved Domains (1) summary
    cd05239
    Location:9 → 312
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

RNA

  1. NR_177931.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Related
    ENSMUST00000229085.2

  2. NR_177932.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

  3. NR_177933.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

  4. NR_177934.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

  5. NR_177935.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

  6. NR_177936.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

  7. NR_177937.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

  8. NR_177938.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Related
    ENSMUST00000230364.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75796532..75801613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23591.3 GenPept UniProtKB/Swiss-Prot:P23591

Gene LinkOut

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