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RNF152 ring finger protein 152 [ Homo sapiens (human) ]

Gene ID: 220441, updated on 5-Mar-2024

Summary

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Official Symbol
RNF152provided by HGNC
Official Full Name
ring finger protein 152provided by HGNC
Primary source
HGNC:HGNC:26811
See related
Ensembl:ENSG00000176641 MIM:616512; AllianceGenome:HGNC:26811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein polyubiquitination. Located in lysosomal membrane. Is integral component of organelle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 29.4), liver (RPKM 4.9) and 13 other tissues See more
Orthologs
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Genomic context

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Location:
18q21.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (61808067..61894412, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (62011910..62098286, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (59475300..59560240, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904315 Neighboring gene long intergenic non-protein coding RNA 1544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:59483460-59484019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9500 Neighboring gene uncharacterized LOC105372159 Neighboring gene uncharacterized LOC112268209 Neighboring gene Sharpr-MPRA regulatory region 15585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9501 Neighboring gene ribose 5-phosphate isomerase A pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression. Wan J, et al. Cancer Cell Int, 2021 Feb 18. PMID 33602225, Free PMC Article
  2. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. Zhang S, et al. Protein Cell, 2010 Jul. PMID 21203937, Free PMC Article
  3. A  conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. Zhang W, et al. PLoS Biol, 2021 Jul. PMID 34297722, Free PMC Article
  4. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. Okamoto T, et al. Int J Mol Sci, 2020 May 30. PMID 32486221, Free PMC Article
  5. Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR-targeted therapy response in colorectal cancer. Li W, et al. Cancer Lett, 2021 Oct 1. PMID 34098062

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
    Title: RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
  2. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
    Title: The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
  3. A mechanism for regulation of mTORC1 signaling by RNF152-mediated K63-linked polyubiquitination of RagA.
    Title: The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
  4. RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities
    Title: RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39176, MGC138161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity EXP
Inferred from Experiment
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in organelle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF152
Names
RING-type E3 ubiquitin transferase RNF152
NP_775828.1
XP_005266707.1
XP_005266709.1
XP_011524180.1
XP_011524181.1
XP_016881101.1
XP_047293305.1
XP_054174259.1
XP_054174260.1
XP_054174261.1
XP_054174262.1
XP_054174263.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173557.3 → NP_775828.1  E3 ubiquitin-protein ligase RNF152

    See identical proteins and their annotated locations for NP_775828.1

    Status: VALIDATED

    Source sequence(s)
    AC105094, AK122758
    Consensus CDS
    CCDS11978.1
    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
    Related
    ENSP00000316628.3, ENST00000312828.4
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    61808067..61894412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266652.4 → XP_005266709.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_005266709.1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  2. XM_017025612.2 → XP_016881101.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  3. XM_005266650.4 → XP_005266707.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_005266707.1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  4. XM_011525878.3 → XP_011524180.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_011524180.1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  5. XM_011525879.3 → XP_011524181.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_011524181.1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  6. XM_047437349.1 → XP_047293305.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    62011910..62098286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318284.1 → XP_054174259.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0

  2. XM_054318285.1 → XP_054174260.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0

  3. XM_054318286.1 → XP_054174261.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0

  4. XM_054318287.1 → XP_054174262.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0

  5. XM_054318288.1 → XP_054174263.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    B3KV99, Q52LA4, Q8N8N0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8N0.1 GenPept UniProtKB/Swiss-Prot:Q8N8N0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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