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GLYATL2 glycine-N-acyltransferase like 2 [ Homo sapiens (human) ]

Gene ID: 219970, updated on 2-Nov-2024

Summary

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Official Symbol
GLYATL2provided by HGNC
Official Full Name
glycine-N-acyltransferase like 2provided by HGNC
Primary source
HGNC:HGNC:24178
See related
Ensembl:ENSG00000156689 MIM:614762; AllianceGenome:HGNC:24178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GATF-B; BXMAS2-10
Summary
Enables glycine N-acyltransferase activity. Involved in long-chain fatty acid catabolic process; medium-chain fatty acid catabolic process; and monounsaturated fatty acid catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in gall bladder (RPKM 3.1), salivary gland (RPKM 1.2) and 5 other tissues See more
Orthologs
all
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Genomic context

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See GLYATL2 in Genome Data Viewer
Location:
11q12.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58834065..58909828, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58783586..58859330, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58601538..58612177, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycine-N-acyltransferase pseudogene Neighboring gene MPRA-validated peak1282 silencer Neighboring gene Sharpr-MPRA regulatory region 12556 Neighboring gene translation machinery associated 16 homolog pseudogene 1 Neighboring gene glycine-N-acyltransferase like 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:58672857-58673356 Neighboring gene glycine-N-acyltransferase like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:58694840-58695354 Neighboring gene uncharacterized LOC283194 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene glycine-N-acyltransferase like 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules. Waluk DP, et al. J Biol Chem, 2012 May 11. PMID 22408254, Free PMC Article
  2. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. Waluk DP, et al. FASEB J, 2010 Aug. PMID 20305126
  3. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. Matsuo M, et al. Biochem Biophys Res Commun, 2012 Apr 20. PMID 22475485
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. acetylation of lysine(s) in hGLYATL2 regulates the enzyme activity, thus linking post-translational modification of proteins with the production of biological signaling molecules, the N-acyl glycines.
    Title: Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules.
  2. report on the characterization of human glycine N-acyltransferase-like 2 (hGLYATL2) and show that it synthesizes various N-acyl glycines.
    Title: Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC24009

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in medium-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monounsaturated fatty acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine N-acyltransferase-like protein 2
Names
acyl-CoA:glycine N-acyltransferase-like protein 2
glycine acyltransferase family-B
NP_659453.3
XP_016872826.1
XP_016872827.1
XP_047282501.1
XP_054223967.1
XP_054223968.1
XP_054223969.1
XP_054223970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145016.4 → NP_659453.3  glycine N-acyltransferase-like protein 2

    See identical proteins and their annotated locations for NP_659453.3

    Status: VALIDATED

    Source sequence(s)
    AP001652, AW264415, BC021682
    Consensus CDS
    CCDS41649.1
    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2
    Related
    ENSP00000287275.1, ENST00000287275.6
    Conserved Domains (2) summary
    pfam08444
    Location:202 → 290
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:10 → 199
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    58834065..58909828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017338.3 → XP_016872827.1  glycine N-acyltransferase-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2
    Conserved Domains (2) summary
    pfam08444
    Location:202 → 290
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:10 → 199
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  2. XM_047426545.1 → XP_047282501.1  glycine N-acyltransferase-like protein 2 isoform X2

  3. XM_017017337.3 → XP_016872826.1  glycine N-acyltransferase-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2
    Related
    ENSP00000434277.1, ENST00000532258.1
    Conserved Domains (2) summary
    pfam08444
    Location:202 → 290
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:10 → 199
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    58783586..58859330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367995.1 → XP_054223970.1  glycine N-acyltransferase-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2

  2. XM_054367993.1 → XP_054223968.1  glycine N-acyltransferase-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2

  3. XM_054367992.1 → XP_054223967.1  glycine N-acyltransferase-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2

  4. XM_054367994.1 → XP_054223969.1  glycine N-acyltransferase-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A5LGC7, Q86WC3, Q8WU03, Q96AT2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WU03.1 GenPept UniProtKB/Swiss-Prot:Q8WU03

Gene LinkOut

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