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UNC5B unc-5 netrin receptor B [ Homo sapiens (human) ]

Gene ID: 219699, updated on 3-Nov-2024

Summary

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Official Symbol
UNC5Bprovided by HGNC
Official Full Name
unc-5 netrin receptor Bprovided by HGNC
Primary source
HGNC:HGNC:12568
See related
Ensembl:ENSG00000107731 MIM:607870; AllianceGenome:HGNC:12568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC5H2; p53RDL1
Summary
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in brain (RPKM 4.8), gall bladder (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

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See UNC5B in Genome Data Viewer
Location:
10q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (71212570..71302864)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (72082200..72172412)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72972327..73062621)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72740721-72741222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72741223-72741722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2458 Neighboring gene uncharacterized LOC105378351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72765166-72765964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72800281-72800928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72821681-72822446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72837401-72838351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72892357-72892910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2459 Neighboring gene Sharpr-MPRA regulatory region 4082 Neighboring gene NANOG hESC enhancer GRCh37_chr10:72975354-72975973 Neighboring gene uncharacterized LOC112268061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72980575-72981076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72992253-72992763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72992809-72993562 Neighboring gene UNC5B antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72995831-72996578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72995071-72995822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72996579-72997325 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:73006150-73007349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73019454-73020306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73025690-73026683 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73026875-73027596 Neighboring gene Sharpr-MPRA regulatory region 4598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73030481-73031200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73039115-73039640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73038590-73039114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73044725-73045226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73045227-73045726 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:73055217-73056024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73063697-73064197 Neighboring gene uncharacterized LOC124902445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2461 Neighboring gene small nucleolar RNA U13 Neighboring gene solute carrier family 29 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical significance of UNC5B expression in bladder cancer. Liu J, et al. Tumour Biol, 2013 Aug. PMID 23055195
  2. UNC-5 netrin receptor B regulates adipogenesis of human adipose-derived stem cells through JNK pathway. Hu X, et al. J Oral Rehabil, 2020 Nov. PMID 32762046
  3. The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells. Huang Y, et al. J Cell Mol Med, 2021 Feb. PMID 33345442, Free PMC Article
  4. Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid cancer via sponging miR-129-5p. Mei S, et al. Int J Biol Markers, 2021 Mar. PMID 33706585
  5. UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS-Mediated P53 Pathway. Yang Z, et al. Oxid Med Cell Longev, 2021. PMID 34239689, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.
    Title: Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.
  2. Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.
    Title: Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.
  3. Delta40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity.
    Title: Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity.
  4. UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS-Mediated P53 Pathway.
    Title: UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS-Mediated P53 Pathway.
  5. UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
    Title: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
  6. Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid cancer via sponging miR-129-5p.
    Title: Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid cancer via sponging miR-129-5p.
  7. The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.
    Title: The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.
  8. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.
    Title: A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.
  9. LncRNA UNC5B-AS1 promotes malignant progression of prostate cancer by competitive binding to caspase-9.
    Title: LncRNA UNC5B-AS1 promotes malignant progression of prostate cancer by competitive binding to caspase-9.
  10. Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease.
    Title: Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
EBI GWAS Catalog
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
netrin receptor UNC5B
Names
p53-regulated receptor for death and life protein 1
protein unc-5 homolog 2
protein unc-5 homolog B
transmembrane receptor Unc5H2
unc-5 homolog 2
unc-5 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244889.2 → NP_001231818.1  netrin receptor UNC5B isoform 2 precursor

    See identical proteins and their annotated locations for NP_001231818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK094595, AK128132, AL049370, AY126437, DA810535
    Consensus CDS
    CCDS58083.1
    UniProtKB/Swiss-Prot
    Q8IZJ1
    Related
    ENSP00000362288.4, ENST00000373192.4
    Conserved Domains (5) summary
    smart00218
    Location:530 → 633
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08802
    Location:847 → 930
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:249 → 300
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:155 → 243
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:157 → 243
    Ig; Immunoglobulin domain

  2. NM_170744.5 → NP_734465.2  netrin receptor UNC5B isoform 1 precursor

    See identical proteins and their annotated locations for NP_734465.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK128132, AL049370, AY358351, DA810535
    Consensus CDS
    CCDS7309.1
    UniProtKB/Swiss-Prot
    Q5T3R9, Q5T3S0, Q86SN3, Q8IZJ1, Q8N1Y2, Q9H9F3
    Related
    ENSP00000334329.6, ENST00000335350.10
    Conserved Domains (5) summary
    smart00218
    Location:541 → 644
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08802
    Location:858 → 941
    Death_UNC5B; Death domain found in Uncoordinated-5B
    smart00209
    Location:249 → 300
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:155 → 243
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:157 → 243
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    71212570..71302864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    72082200..72172412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZJ1.2 GenPept UniProtKB/Swiss-Prot:Q8IZJ1

Gene LinkOut

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