Tlr1 toll-like receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr1provided by MGI
Official Full Name: toll-like receptor 1provided by MGI
Primary source: MGI:MGI:1341295
See related: Ensembl:ENSMUSG00000044827 AllianceGenome:MGI:1341295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 12.1), colon adult (RPKM 6.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 33.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (65082023..65090945, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (64924680..64933600, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206[+] macrophages[IL-10] activation.
Title: Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206(+) macrophages(IL-10) activation.
The findings demonstrate that sensing of the microbiota by TLR1 may provide key signals that regulate the colonic epithelium, thereby limiting inflammation through the prevention of bacterial attachment to the mucosa and exposure to the underlying immune system.
Title: Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.
These studies reveal that the costimulatory effects of TLR1-TLR2 signaling in CD8(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response.
Title: Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects.
Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders.
Title: Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.
B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination, modulated by BCR and CD40 in mounting of T-cell independent antibody responses.
Title: B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.
TLR9 modulates TLR1 expression in Leishmania major-infected macrophages.
Title: TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages.
Postradiotherapeutic NO production was dependent on TLR1 gene expression. Although iNOS activity was reduced by inhibiting TLR1 expression with TLR1-siRNA, it was enhanced by TLR1 overexpression.
Title: γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages.
lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface.
Title: Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.
We found that CEP specifically synergizes with low-dose TLR2-agonists (but not agonists for other TLRs) to induce production of inflammatory cytokines. Moreover, CEP selectively augments TLR2/TLR1-signaling instead of TLR2/TLR6-signaling
Title: The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages.
IkappaB-zeta regulates TLR-mediated CSR by inducing AID
Title: Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll-like receptor 2 binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables triacyl lipopeptide binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of NF-kappaB-inducing kinase activity	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to triacyl bacterial lipopeptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to triacyl bacterial lipopeptide	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in detection of triacyl bacterial lipopeptide	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation	NAS Non-traceable Author Statement more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterial lipoprotein	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	NAS Non-traceable Author Statement more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-like receptor 1

Names: TIL; toll/interleukin-1 receptor-like protein

NP_001263374.1

EC 3.2.2.6

NP_109607.1

EC 3.2.2.6

XP_006503914.1

EC 3.2.2.6

XP_006503916.1

EC 3.2.2.6

XP_006503917.1

EC 3.2.2.6

XP_006503919.1

EC 3.2.2.6

XP_011239022.1

EC 3.2.2.6

XP_030110223.1

EC 3.2.2.6

XP_036020886.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276445.1 → NP_001263374.1 toll-like receptor 1 precursor

See identical proteins and their annotated locations for NP_001263374.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC161757

Consensus CDS

CCDS19302.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Related

ENSMUSP00000142500.2, ENSMUST00000197315.5

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
NM_030682.2 → NP_109607.1 toll-like receptor 1 precursor

See identical proteins and their annotated locations for NP_109607.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC161757, AY009154

Consensus CDS

CCDS19302.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Related

ENSMUSP00000060793.5, ENSMUST00000059349.6

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

65082023..65090945 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503854.2 → XP_006503917.1 toll-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006503917.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
XM_006503853.3 → XP_006503916.1 toll-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006503916.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
XM_030254363.2 → XP_030110223.1 toll-like receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
XM_006503856.3 → XP_006503919.1 toll-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006503919.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
XM_036164993.1 → XP_036020886.1 toll-like receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
XM_006503851.4 → XP_006503914.1 toll-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006503914.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]
XM_011240720.4 → XP_011239022.1 toll-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_011239022.1

UniProtKB/Swiss-Prot

Q9EPQ1, Q9EPW5

UniProtKB/TrEMBL

B9EJ46, Q6A0E8

Conserved Domains (6) summary

PRK15370
Location:377 → 487

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:527 → 581

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:639 → 782

TIR; Toll - interleukin 1 - resistance

COG4886
Location:48 → 317

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:355 → 376

LRR_RI; leucine-rich repeat [structural motif]