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Arl15 ADP-ribosylation factor-like 15 [ Mus musculus (house mouse) ]

Gene ID: 218639, updated on 2-Nov-2024

Summary

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Official Symbol
Arl15provided by MGI
Official Full Name
ADP-ribosylation factor-like 15provided by MGI
Primary source
MGI:MGI:2442308
See related
Ensembl:ENSMUSG00000042348 AllianceGenome:MGI:2442308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arfrp2; A430036I03; C230032K13Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and nasal septum. Orthologous to human ARL15 (ADP ribosylation factor like GTPase 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 3.6), CNS E18 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arl15 in Genome Data Viewer
Location:
13 D2.2; 13 64.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113929963..114293998)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113794506..114157462)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31276 Neighboring gene STARR-positive B cell enhancer ABC_E933 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35739 Neighboring gene STARR-positive B cell enhancer ABC_E7291 Neighboring gene STARR-seq mESC enhancer starr_35743 Neighboring gene STARR-seq mESC enhancer starr_35745 Neighboring gene RIKEN cDNA A430090L17 gene Neighboring gene STARR-seq mESC enhancer starr_35752 Neighboring gene predicted gene, 41072 Neighboring gene STARR-seq mESC enhancer starr_35753 Neighboring gene STARR-seq mESC enhancer starr_35756 Neighboring gene STARR-seq mESC enhancer starr_35758 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:115178183-115178393

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. Rocha N, et al. Sci Rep, 2017 Dec 14. PMID 29242557, Free PMC Article
  2. Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout. Bai Y, et al. FASEB J, 2023 Nov. PMID 37773757, Free PMC Article
  3. ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity. Zhao J, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28322786
  4. Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes. Gupta N, et al. Cell Rep, 2023 Oct 31. PMID 37824328, Free PMC Article
  5. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.
    Title: Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.
  2. ARL15 plays a role in adipocyte differentiation and adiponectin secretion
    Title: The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
  3. In conclusion, we have identified that ARL15 acts as an insulin-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1/AKT insulin pathway by interacting with its GAP ASAP2 and activating PDPK1. This research may provide new insights into GTPase-mediated insulin signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin sensitizati
    Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 15
Names
ADP-ribosylation factor related protein 2
ARF-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172595.5 → NP_766183.1  ADP-ribosylation factor-like protein 15

    See identical proteins and their annotated locations for NP_766183.1

    Status: VALIDATED

    Source sequence(s)
    AC126939, AC154862
    Consensus CDS
    CCDS36785.1
    UniProtKB/Swiss-Prot
    Q8BGR6
    Related
    ENSMUSP00000088740.7, ENSMUST00000091201.7
    Conserved Domains (2) summary
    COG1100
    Location:31 → 197
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cl21455
    Location:34 → 193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    113929963..114293998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517630.4 → XP_006517693.1  ADP-ribosylation factor-like protein 15 isoform X4

    See identical proteins and their annotated locations for XP_006517693.1

    UniProtKB/TrEMBL
    B7ZN40
    Related
    ENSMUSP00000153127.2, ENSMUST00000224068.2
    Conserved Domains (1) summary
    cl38936
    Location:34 → 173
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006517629.5 → XP_006517692.1  ADP-ribosylation factor-like protein 15 isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:34 → 165
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_030247239.2 → XP_030103099.1  ADP-ribosylation factor-like protein 15 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:34 → 193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_011244655.4 → XP_011242957.1  ADP-ribosylation factor-like protein 15 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:26 → 185
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGR6.1 GenPept UniProtKB/Swiss-Prot:Q8BGR6

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