Il31ra interleukin 31 receptor A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il31raprovided by MGI
Official Full Name: interleukin 31 receptor Aprovided by MGI
Primary source: MGI:MGI:2180511
See related: Ensembl:ENSMUSG00000050377 AllianceGenome:MGI:2180511
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPL; CRL3; Glmr; NR10; GLM-R
Summary: Enables cytokine binding activity. Acts upstream of or within acute inflammatory response to antigenic stimulus; defense response to other organism; and glandular epithelial cell differentiation. Located in external side of plasma membrane. Is expressed in brain; peripheral nervous system; reproductive system; and stomach. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 2. Orthologous to human IL31RA (interleukin 31 receptor A). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.75 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (112649439..112717266, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (112521931..112580732, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin 31 receptor alpha promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
Title: Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of Mice with Atopic Dermatitis.
Title: Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of Mice with Atopic Dermatitis.
The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis.
Title: The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis.
IL-31 upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA expression in mice
Title: Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice.
Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice
Title: Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice.
IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch.
Title: A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
Title: IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent immunity and inflammation following intestinal helminth infection.
Gp130(757F/F) mice rapidly develop distal stomach tumors, with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified by decreased TFF1 expression and increased STAT1/3 regulated genes such as Reg I.
Title: Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.
IL-31 receptor alpha signaling is a novel negative regulatory pathway that specifically limits T helper cell type 2 inflammation.
Title: IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to other organism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glandular epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-31 receptor subunit alpha

Names: IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; class I cytokine receptor; cytokine receptor NR10; gp130-like monocyte receptor; gp130-like receptor; interleukin 31RA; interleukin-31 receptor subunit alpha short peptide; mGLM-R; novel cytokine receptor 10; zcytoR17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139299.2 → NP_647460.2 interleukin-31 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_647460.2

Status: VALIDATED

Source sequence(s)

AB083111, AC159196, AK030512, BC066164, BC145083

Consensus CDS

CCDS36781.1

UniProtKB/Swiss-Prot

E9QQ31, Q6EAL6, Q6EAL7, Q6NZF0, Q8BSU3, Q8K5B1, Q8R501

UniProtKB/TrEMBL

A0A249JQT6

Related

ENSMUSP00000058045.7, ENSMUST00000051756.8

Conserved Domains (2) summary

smart00060
Location:415 → 488

FN3; Fibronectin type 3 domain

cd00063
Location:116 → 208

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

112649439..112717266 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158028.1 → XP_036013921.1 interleukin-31 receptor subunit alpha isoform X5

Conserved Domains (2) summary

smart00060
Location:432 → 505

FN3; Fibronectin type 3 domain

cd00063
Location:133 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006517620.4 → XP_006517683.1 interleukin-31 receptor subunit alpha isoform X1

UniProtKB/TrEMBL

A0A249JQT6

Conserved Domains (2) summary

smart00060
Location:432 → 505

FN3; Fibronectin type 3 domain

cd00063
Location:133 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006517621.4 → XP_006517684.1 interleukin-31 receptor subunit alpha isoform X2

See identical proteins and their annotated locations for XP_006517684.1

UniProtKB/Swiss-Prot

E9QQ31, Q6EAL6, Q6EAL7, Q6NZF0, Q8BSU3, Q8K5B1, Q8R501

UniProtKB/TrEMBL

A0A249JQT6

Conserved Domains (2) summary

smart00060
Location:415 → 488

FN3; Fibronectin type 3 domain

cd00063
Location:116 → 208

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017315499.3 → XP_017170988.1 interleukin-31 receptor subunit alpha isoform X2

UniProtKB/Swiss-Prot

E9QQ31, Q6EAL6, Q6EAL7, Q6NZF0, Q8BSU3, Q8K5B1, Q8R501

UniProtKB/TrEMBL

A0A249JQT6

Conserved Domains (2) summary

smart00060
Location:415 → 488

FN3; Fibronectin type 3 domain

cd00063
Location:116 → 208

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006517623.3 → XP_006517686.1 interleukin-31 receptor subunit alpha isoform X3

See identical proteins and their annotated locations for XP_006517686.1

UniProtKB/TrEMBL

A0A249JQT6, A0A286YDE2

Related

ENSMUSP00000153382.2, ENSMUST00000224510.2

Conserved Domains (2) summary

smart00060
Location:334 → 407

FN3; Fibronectin type 3 domain

cd00063
Location:35 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017315500.3 → XP_017170989.1 interleukin-31 receptor subunit alpha isoform X3

UniProtKB/TrEMBL

A0A249JQT6, A0A286YDE2

Conserved Domains (2) summary

smart00060
Location:334 → 407

FN3; Fibronectin type 3 domain

cd00063
Location:35 → 127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036158027.1 → XP_036013920.1 interleukin-31 receptor subunit alpha isoform X4

Conserved Domains (2) summary

smart00060
Location:432 → 505

FN3; Fibronectin type 3 domain

cd00063
Location:133 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...