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Sgtb small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [ Mus musculus (house mouse) ]

Gene ID: 218544, updated on 2-Nov-2024

Summary

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Official Symbol
Sgtbprovided by MGI
Official Full Name
small glutamine-rich tetratricopeptide repeat (TPR)-containing, betaprovided by MGI
Primary source
MGI:MGI:2444615
See related
Ensembl:ENSMUSG00000042743 AllianceGenome:MGI:2444615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C630001O05Rik
Summary
Predicted to enable Hsp70 protein binding activity; molecular adaptor activity; and protein dimerization activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane; protein heterooligomerization; and protein homooligomerization. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in nervous system and sensory organ. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 25.8), frontal lobe adult (RPKM 19.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Sgtb in Genome Data Viewer
Location:
13 D1; 13 56.23 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104246233..104278369)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104109723..104141861)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Erbb2 interacting protein Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene STARR-positive B cell enhancer ABC_E8543 Neighboring gene STARR-seq mESC enhancer starr_35524 Neighboring gene STARR-seq mESC enhancer starr_35525 Neighboring gene STARR-seq mESC enhancer starr_35526 Neighboring gene STARR-seq mESC enhancer starr_35527 Neighboring gene STARR-seq mESC enhancer starr_35528 Neighboring gene STARR-seq mESC enhancer starr_35530 Neighboring gene predicted gene, 30967 Neighboring gene neurolysin (metallopeptidase M3 family) Neighboring gene STARR-positive B cell enhancer mm9_chr13:104881886-104882187 Neighboring gene STARR-positive B cell enhancer ABC_E3099 Neighboring gene trafficking protein particle complex 13 Neighboring gene STARR-positive B cell enhancer ABC_E8896 Neighboring gene STARR-positive B cell enhancer ABC_E385 Neighboring gene STARR-seq mESC enhancer starr_35535 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth. Vuong TA, et al. Cell Signal, 2019 Mar. PMID 30639199
  2. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, et al. J Biol Chem, 2003 Oct 3. PMID 12878599
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small glutamine-rich tetratricopeptide repeat-containing protein beta
Names
beta-SGT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361054.1 → NP_001347983.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

    Status: VALIDATED

    Source sequence(s)
    AC154216
    Consensus CDS
    CCDS26746.1
    UniProtKB/Swiss-Prot
    Q8VD33
    Conserved Domains (3) summary
    sd00006
    Location:85 → 113
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:5 → 64
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:85 → 237
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

  2. NM_144838.2 → NP_659087.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

    See identical proteins and their annotated locations for NP_659087.1

    Status: VALIDATED

    Source sequence(s)
    AC154216, BC017611
    Consensus CDS
    CCDS26746.1
    UniProtKB/Swiss-Prot
    Q8VD33
    Related
    ENSMUSP00000041307.8, ENSMUST00000044385.14
    Conserved Domains (3) summary
    sd00006
    Location:85 → 113
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:5 → 64
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:85 → 237
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    104246233..104278369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950448.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD33.1 GenPept UniProtKB/Swiss-Prot:Q8VD33

Gene LinkOut

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