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Ankrd34b ankyrin repeat domain 34B [ Mus musculus (house mouse) ]

Gene ID: 218440, updated on 17-Aug-2024

Summary

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Official Symbol
Ankrd34bprovided by MGI
Official Full Name
ankyrin repeat domain 34Bprovided by MGI
Primary source
MGI:MGI:2443245
See related
Ensembl:ENSMUSG00000045034 AllianceGenome:MGI:2443245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DP58; 6430502M16Rik
Summary
Predicted to be located in cytoplasm and nucleus. Orthologous to human ANKRD34B (ankyrin repeat domain 34B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 4.7), frontal lobe adult (RPKM 1.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd34b in Genome Data Viewer
Location:
13 C3; 13 47.68 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92562413..92578166)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (92425905..92441658)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene mutS homolog 3 Neighboring gene STARR-positive B cell enhancer mm9_chr13:93090941-93091242 Neighboring gene predicted gene, 20379 Neighboring gene STARR-positive B cell enhancer ABC_E8539 Neighboring gene STARR-positive B cell enhancer ABC_E2416 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene dihydrofolate reductase Neighboring gene family with sequence similarity 151, member B Neighboring gene STARR-seq mESC enhancer starr_35266 Neighboring gene predicted gene, 52060 Neighboring gene zinc finger, FYVE domain containing 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel cell-surface protein CSP82 on bone marrow stem cells and a cytosolic phosphoprotein DP58 (ankyrinRD 34B) are involved in promyeloid progenitor induction. Al-Shaibi N, et al. Cell Immunol, 2009. PMID 19524877
  2. A novel phosphoprotein is induced during bone marrow commitment to dendritic cells. Al-Shaibi N, et al. Biochem Biophys Res Commun, 2004 Aug 13. PMID 15358210
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytosolic phosphoprotein DP58 is involved in promyeloid progenitor induction.
    Title: A novel cell-surface protein CSP82 on bone marrow stem cells and a cytosolic phosphoprotein DP58 (ankyrinRD 34B) are involved in promyeloid progenitor induction.
  2. Because of its restricted expression in bone-marrow-drived progenitors as a phophorylated protein, it is likely that DP58 may be involved in a signaling pathway for cellular differentiation.
    Title: A novel phosphoprotein is induced during bone marrow commitment to dendritic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 34B
Names
cytosolic phosphoprotein DP58
dendritic cell progenitor protein of 58 kDa
dendritic phosphoprotein 58 kDa
dendritic protein of 58 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175455.4 → NP_780664.2  ankyrin repeat domain-containing protein 34B

    See identical proteins and their annotated locations for NP_780664.2

    Status: VALIDATED

    Source sequence(s)
    AK078203, AK138465, AW489260, BC119314, BE649643
    Consensus CDS
    CCDS26681.1
    UniProtKB/Swiss-Prot
    Q3UUF8, Q4VA01, Q8BVH7
    Related
    ENSMUSP00000054330.7, ENSMUST00000061594.13
    Conserved Domains (2) summary
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:31 → 115
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    92562413..92578166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244638.3 → XP_011242940.1  ankyrin repeat domain-containing protein 34B isoform X1

    See identical proteins and their annotated locations for XP_011242940.1

    UniProtKB/Swiss-Prot
    Q3UUF8, Q4VA01, Q8BVH7
    Conserved Domains (2) summary
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:31 → 115
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036158011.1 → XP_036013904.1  ankyrin repeat domain-containing protein 34B isoform X1

    UniProtKB/Swiss-Prot
    Q3UUF8, Q4VA01, Q8BVH7
    Related
    ENSMUSP00000126289.2, ENSMUST00000168871.2
    Conserved Domains (2) summary
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:31 → 115
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UUF8.1 GenPept UniProtKB/Swiss-Prot:Q3UUF8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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