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Eif4e1b eukaryotic translation initiation factor 4E family member 1B [ Mus musculus (house mouse) ]

Gene ID: 218268, updated on 2-Nov-2024

Summary

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Official Symbol
Eif4e1bprovided by MGI
Official Full Name
eukaryotic translation initiation factor 4E family member 1Bprovided by MGI
Primary source
MGI:MGI:2685119
See related
Ensembl:ENSMUSG00000074895 AllianceGenome:MGI:2685119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm273; Eif4eloo
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in early conceptus and reproductive system. Orthologous to human EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward ovary adult (RPKM 4.5) See more
Orthologs
human all
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Genomic context

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See Eif4e1b in Genome Data Viewer
Location:
13 B1; 13 29.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54931807..54936272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54783994..54788459)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene synuclein, beta Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249 Neighboring gene STARR-positive B cell enhancer mm9_chr13:54890539-54890840 Neighboring gene tetraspanin 17 Neighboring gene predicted gene, 40959

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. Guo J, et al. Adv Sci (Weinh), 2023 Apr. PMID 36755190, Free PMC Article
  2. Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Yang G, et al. Genes Dev, 2023 May 1. PMID 37257918, Free PMC Article
  3. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Wan Y, et al. Nucleic Acids Res, 2023 Nov 27. PMID 37889087, Free PMC Article
  4. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. Lorenzo-Orts L, et al. EMBO Rep, 2024 Jan. PMID 38177902, Free PMC Article
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.
    Title: eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.
  2. Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation.
    Title: Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation.
  3. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.
    Title: Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7)  1 citation
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4E type 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033269.3 → NP_001028441.1  eukaryotic translation initiation factor 4E type 1B isoform 1

    See identical proteins and their annotated locations for NP_001028441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    DQ279473, DV659735
    Consensus CDS
    CCDS49269.1
    UniProtKB/Swiss-Prot
    Q27ZJ1, Q3UTA9
    UniProtKB/TrEMBL
    E9Q0M0
    Related
    ENSMUSP00000123294.2, ENSMUST00000132728.8
    Conserved Domains (1) summary
    pfam01652
    Location:66 → 225
    IF4E; Eukaryotic initiation factor 4E

  2. NM_001039683.2 → NP_001034772.1  eukaryotic translation initiation factor 4E type 1B isoform 2

    See identical proteins and their annotated locations for NP_001034772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    DQ279473, DQ279474, DV659735
    Consensus CDS
    CCDS49270.1
    UniProtKB/Swiss-Prot
    Q3UTA9
    Related
    ENSMUSP00000120619.2, ENSMUST00000152204.3
    Conserved Domains (1) summary
    pfam01652
    Location:66 → 161
    IF4E; Eukaryotic initiation factor 4E

  3. NM_001286178.1 → NP_001273107.1  eukaryotic translation initiation factor 4E type 1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    DQ279473, DV653822, DV659735
    UniProtKB/TrEMBL
    E9Q0M0
    Related
    ENSMUSP00000117092.2, ENSMUST00000142158.8
    Conserved Domains (1) summary
    pfam01652
    Location:74 → 230
    IF4E; Eukaryotic initiation factor 4E

  4. NM_001286179.1 → NP_001273108.1  eukaryotic translation initiation factor 4E type 1B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (4) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    DQ279473, DV659735, DV662251
    Consensus CDS
    CCDS70460.1
    UniProtKB/TrEMBL
    E9PVZ9, E9Q0M0
    Related
    ENSMUSP00000118697.3, ENSMUST00000126785.8
    Conserved Domains (1) summary
    pfam01652
    Location:75 → 231
    IF4E; Eukaryotic initiation factor 4E

  5. NM_001286180.1 → NP_001273109.1  eukaryotic translation initiation factor 4E type 1B isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate splice sites in the 5'-terminal exon and in the 3' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (5) has a longer N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    DQ279473, DV659735, DV662389
    Consensus CDS
    CCDS70459.1
    UniProtKB/TrEMBL
    E9Q929
    Related
    ENSMUSP00000116681.2, ENSMUST00000132005.8
    Conserved Domains (1) summary
    pfam01652
    Location:74 → 166
    IF4E; Eukaryotic initiation factor 4E

RNA

  1. NR_104406.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    DQ279473, DQ279478, DV659735

  2. NR_104407.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two internal exons and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    DQ279473, DQ279479, DV659735

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54931807..54936272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315485.2 → XP_017170974.1  eukaryotic translation initiation factor 4E type 1B isoform X1

    UniProtKB/Swiss-Prot
    Q27ZJ1, Q3UTA9
    UniProtKB/TrEMBL
    E9Q0M0
    Related
    ENSMUSP00000105630.3, ENSMUST00000110003.9
    Conserved Domains (1) summary
    pfam01652
    Location:66 → 225
    IF4E; Eukaryotic initiation factor 4E

  2. XM_017315486.2 → XP_017170975.1  eukaryotic translation initiation factor 4E type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q3UTA9
    Conserved Domains (1) summary
    pfam01652
    Location:66 → 161
    IF4E; Eukaryotic initiation factor 4E
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UTA9.1 GenPept UniProtKB/Swiss-Prot:Q3UTA9

Gene LinkOut

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