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Gmds GDP-mannose 4, 6-dehydratase [ Mus musculus (house mouse) ]

Gene ID: 218138, updated on 28-Oct-2024

Summary

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Official Symbol
Gmdsprovided by MGI
Official Full Name
GDP-mannose 4, 6-dehydrataseprovided by MGI
Primary source
MGI:MGI:1891112
See related
Ensembl:ENSMUSG00000038372 AllianceGenome:MGI:1891112
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GDP-mannose 4,6-dehydratase activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process and Notch signaling pathway. Is active in cytosol. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in large intestine adult (RPKM 98.5), colon adult (RPKM 91.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Gmds in Genome Data Viewer
Location:
13 A3.2; 13 13.52 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32003566..32522744, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (31819583..32338762, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34088 Neighboring gene predicted gene 11379 Neighboring gene forkhead box C1 Neighboring gene STARR-seq mESC enhancer starr_34090 Neighboring gene 60S ribosomal protein L17-like Neighboring gene predicted gene, 52056 Neighboring gene predicted gene, 35732 Neighboring gene STARR-seq mESC enhancer starr_34094 Neighboring gene STARR-seq mESC enhancer starr_34095 Neighboring gene predicted gene, 35672 Neighboring gene STARR-seq mESC enhancer starr_34096 Neighboring gene predicted gene, 52055 Neighboring gene STARR-seq mESC enhancer starr_34097 Neighboring gene STARR-seq mESC enhancer starr_34099 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:32430680-32430789 Neighboring gene STARR-seq mESC enhancer starr_34100 Neighboring gene predicted gene 11381 Neighboring gene STARR-seq mESC enhancer starr_34101 Neighboring gene predicted gene, 40876

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3. Kizuka Y, et al. Cell Chem Biol, 2017 Dec 21. PMID 29033318
  2. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Xu J, et al. Front Cell Dev Biol, 2021. PMID 33898467, Free PMC Article
  3. Endothelial Cyp26b1 restrains murine heart valve growth during development. Ahuja N, et al. Dev Biol, 2022 Jun. PMID 35364055
  4. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. Sullivan FX, et al. J Biol Chem, 1998 Apr 3. PMID 9525924
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC18773, MGC103045

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-mannose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-mannose 4,6-dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose 4,6-dehydratase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables GDP-mannose 4,6-dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADP+ binding ISO
Inferred from Sequence Orthology
more info
  
enables NADP+ binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in 'de novo' GDP-L-fucose biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in GDP-mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-mannose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP-mannose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GDP-mannose 4,6 dehydratase
Names
GDP-D-mannose dehydratase
GMD
NP_666153.1
XP_006516719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146041.2 → NP_666153.1  GDP-mannose 4,6 dehydratase

    See identical proteins and their annotated locations for NP_666153.1

    Status: PROVISIONAL

    Source sequence(s)
    AL645643, AL645664, AL645697, AL645763, AL645783
    Consensus CDS
    CCDS26426.1
    UniProtKB/Swiss-Prot
    Q8K0C9
    Related
    ENSMUSP00000036696.8, ENSMUST00000041859.9
    Conserved Domains (2) summary
    TIGR01472
    Location:24 → 366
    gmd; GDP-mannose 4,6-dehydratase
    pfam16363
    Location:27 → 358
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    32003566..32522744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516656.4 → XP_006516719.1  GDP-mannose 4,6 dehydratase isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:34 → 285
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0C9.1 GenPept UniProtKB/Swiss-Prot:Q8K0C9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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