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Coq6 coenzyme Q6 monooxygenase [ Mus musculus (house mouse) ]

Gene ID: 217707, updated on 28-Oct-2024

Summary

Official Symbol
Coq6provided by MGI
Official Full Name
coenzyme Q6 monooxygenaseprovided by MGI
Primary source
MGI:MGI:1924408
See related
Ensembl:ENSMUSG00000021235 AllianceGenome:MGI:1924408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5930427M12Rik
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in epididymis; heart; heart right ventricle; metanephros; and testis. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in heart adult (RPKM 30.2), adrenal adult (RPKM 26.7) and 28 other tissues See more
Orthologs
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Genomic context

See Coq6 in Genome Data Viewer
Location:
12 D1; 12 39.18 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84408530..84420570)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84361756..84373796)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene prostaglandin reductase 2 Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquinone biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquinone biosynthesis complex IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Names
coenzyme Q10 monooxygenase 6
coenzyme Q6 homolog
NP_766170.2
XP_006515762.1
XP_006515763.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172582.3NP_766170.2  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_766170.2

    Status: VALIDATED

    Source sequence(s)
    AC120402, BC132170
    Consensus CDS
    CCDS26044.1
    UniProtKB/Swiss-Prot
    Q3TJM2, Q80V13, Q8BJY5, Q8R1S0
    UniProtKB/TrEMBL
    D3YW66
    Related
    ENSMUSP00000021661.7, ENSMUST00000021661.13
    Conserved Domains (1) summary
    cl21454
    Location:57471
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84408530..84420570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515699.2XP_006515762.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006515762.1

    UniProtKB/Swiss-Prot
    Q3TJM2, Q80V13, Q8BJY5, Q8R1S0
    UniProtKB/TrEMBL
    D3YW66
    Related
    ENSMUSP00000105905.2, ENSMUST00000110276.8
    Conserved Domains (1) summary
    cl21454
    Location:57471
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_006515700.2XP_006515763.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:45388
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_381514.3 RNA Sequence

    Related
    ENSMUST00000152913.8