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Dgkb diacylglycerol kinase, beta [ Mus musculus (house mouse) ]

Gene ID: 217480, updated on 2-Nov-2024

Summary

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Official Symbol
Dgkbprovided by MGI
Official Full Name
diacylglycerol kinase, betaprovided by MGI
Primary source
MGI:MGI:2442474
See related
Ensembl:ENSMUSG00000036095 AllianceGenome:MGI:2442474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DGK; 90kda; DAGK2; DGK-beta; mKIAA0718; 6430574F24; C630029D13Rik
Summary
Enables ATP-dependent diacylglycerol kinase activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within response to bacterium. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in anterior abdominal wall musculature; nervous system; retina; and urinary system. Orthologous to human DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 12.9), cortex adult (RPKM 7.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Dgkb in Genome Data Viewer
Location:
12 A3; 12 17.11 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (37930169..38684238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (37880169..38634239)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31928 Neighboring gene mesenchyme homeobox 2 Neighboring gene alkylglycerol monooxygenase Neighboring gene predicted gene, 34408 Neighboring gene STARR-seq mESC enhancer starr_31930 Neighboring gene STARR-seq mESC enhancer starr_31931 Neighboring gene STARR-seq mESC enhancer starr_31932 Neighboring gene STARR-seq mESC enhancer starr_31933 Neighboring gene STARR-seq mESC enhancer starr_31934 Neighboring gene STARR-seq mESC enhancer starr_31935 Neighboring gene predicted gene, 35755 Neighboring gene predicted gene, 52011 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31936 Neighboring gene RIKEN cDNA 4930428E07 gene Neighboring gene STARR-seq mESC enhancer starr_31937 Neighboring gene STARR-seq mESC enhancer starr_31938 Neighboring gene STARR-seq mESC enhancer starr_31940 Neighboring gene phosphatidylethanolamine binding protein 2 pseudogene Neighboring gene ets variant 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice. Kakefuda K, et al. Neurosci Lett, 2016 Sep 6. PMID 27495014
  2. Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons. Hozumi Y, et al. Brain Res, 2015 Jan 12. PMID 25446448
  3. Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity. Ishisaka M, et al. PLoS One, 2012. PMID 22590645, Free PMC Article
  4. Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function. Shirai Y, et al. PLoS One, 2010 Jul 15. PMID 20657643, Free PMC Article
  5. Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. Schlam D, et al. J Biol Chem, 2013 Aug 9. PMID 23814057, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Memantine, an NMDA receptor antagonist, improves working memory deficits in Diacylglycerol kinase (DGK) beta knockout mice. These findings may support the hypothesis that DGKbeta has a pivotal role in cognitive function.
    Title: Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice.
  2. These findings suggest that DGKbeta regulates the spine formation at distal dendrites in medium spiny neurons
    Title: Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons.
  3. This study demonistrated that Dgkb distribuate in mice cerebellum
    Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
  4. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst.
    Title: Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.
  5. that DGKbeta KO mice showed attention-deficit and hyperactive phenotype, similar to ADHD.
    Title: Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity.
  6. Results demonstrate that membrane-localized DGKbeta regulates spine formation by regulation of lipids, contributing to the maintenance of neural networks in synaptic transmission of cognitive processes including memory.
    Title: Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Transposon induced (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diacylglycerol kinase beta
Names
DAG kinase beta
diglyceride kinase beta
NP_001348615.1
NP_001348617.1
NP_848796.2
XP_006515130.1
XP_006515131.1
XP_006515133.1
XP_006515134.1
XP_017170508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361686.1 → NP_001348615.1  diacylglycerol kinase beta isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116471, AC141479, AC157494, AC157821, AC166996, CT009742, CT025577
    UniProtKB/Swiss-Prot
    Q6NS52, Q80TT5
    Conserved Domains (6) summary
    smart00045
    Location:580 → 760
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:438 → 559
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:244 → 293
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:309 → 358
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. NM_001361688.1 → NP_001348617.1  diacylglycerol kinase beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK139408, AK161933, AW493391, BC070461, BG088459
    Consensus CDS
    CCDS25889.1
    Related
    ENSMUSP00000152378.2, ENSMUST00000220990.2
    Conserved Domains (6) summary
    smart00045
    Location:573 → 753
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:431 → 552
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:237 → 286
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:145 → 214
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:302 → 353
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7 → 141
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. NM_178681.5 → NP_848796.2  diacylglycerol kinase beta isoform 2

    See identical proteins and their annotated locations for NP_848796.2

    Status: VALIDATED

    Source sequence(s)
    AK139408, AW493391, BG088459, CJ128305
    Consensus CDS
    CCDS25889.1
    UniProtKB/Swiss-Prot
    Q6NS52
    Related
    ENSMUSP00000037900.8, ENSMUST00000040500.9
    Conserved Domains (6) summary
    smart00045
    Location:573 → 753
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:431 → 552
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:237 → 286
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:145 → 214
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:302 → 353
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:7 → 141
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    37930169..38684238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515068.4 → XP_006515131.1  diacylglycerol kinase beta isoform X1

    See identical proteins and their annotated locations for XP_006515131.1

    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:244 → 293
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:309 → 358
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. XM_017315019.3 → XP_017170508.1  diacylglycerol kinase beta isoform X2

    UniProtKB/Swiss-Prot
    Q6NS52, Q80TT5
    Conserved Domains (6) summary
    smart00045
    Location:580 → 760
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:438 → 559
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:244 → 293
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:309 → 358
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. XM_006515071.3 → XP_006515134.1  diacylglycerol kinase beta isoform X3

    See identical proteins and their annotated locations for XP_006515134.1

    Conserved Domains (6) summary
    smart00045
    Location:574 → 754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432 → 553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:237 → 286
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:145 → 214
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:302 → 351
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 141
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  4. XM_006515070.4 → XP_006515133.1  diacylglycerol kinase beta isoform X3

    See identical proteins and their annotated locations for XP_006515133.1

    Conserved Domains (6) summary
    smart00045
    Location:574 → 754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432 → 553
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:237 → 286
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:145 → 214
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:302 → 351
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 141
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. XM_006515067.3 → XP_006515130.1  diacylglycerol kinase beta isoform X1

    See identical proteins and their annotated locations for XP_006515130.1

    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:244 → 293
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:309 → 358
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NS52.2 GenPept UniProtKB/Swiss-Prot:Q6NS52

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