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Ankmy2 ankyrin repeat and MYND domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 217473, updated on 2-Nov-2024

Summary

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Official Symbol
Ankmy2provided by MGI
Official Full Name
ankyrin repeat and MYND domain containing 2provided by MGI
Primary source
MGI:MGI:2144755
See related
Ensembl:ENSMUSG00000036188 AllianceGenome:MGI:2144755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZMYND20
Summary
Enables enzyme binding activity. Predicted to be located in cilium. Is expressed in brain; spinal cord; tail dorsal root ganglion; and trigeminal ganglion. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 13.0), bladder adult (RPKM 11.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ankmy2 in Genome Data Viewer
Location:
12 A3; 12 16.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (36207123..36247290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (36157124..36197291)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2F (putative), retrotransposed Neighboring gene basic leucine zipper and W2 domains 2 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_31915 Neighboring gene STARR-positive B cell enhancer ABC_E1153 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene leucine rich repeat containing 72 Neighboring gene STARR-seq mESC enhancer starr_31916 Neighboring gene predicted gene, 40390 Neighboring gene STARR-seq mESC enhancer starr_31918 Neighboring gene predicted gene, 40392 Neighboring gene STARR-seq mESC enhancer starr_31919

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis. Hwang SH, et al. PLoS Genet, 2023 Nov. PMID 37943875, Free PMC Article
  2. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. Jensen VL, et al. PLoS Genet, 2010 Nov 24. PMID 21124868, Free PMC Article
  3. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling. Somatilaka BN, et al. Dev Cell, 2020 Sep 28. PMID 32702291, Free PMC Article
  4. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. Saita S, et al. J Biol Chem, 2014 Sep 12. PMID 25077969, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.
    Title: Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.
  2. Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo
    Title: Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC18754

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and MYND domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146033.3 → NP_666145.3  ankyrin repeat and MYND domain-containing protein 2

    See identical proteins and their annotated locations for NP_666145.3

    Status: VALIDATED

    Source sequence(s)
    AK077556, AK164434, BF453918, BY069852
    Consensus CDS
    CCDS25885.1
    UniProtKB/Swiss-Prot
    Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1
    Related
    ENSMUSP00000039484.4, ENSMUST00000041640.5
    Conserved Domains (4) summary
    cd00204
    Location:30 → 132
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01753
    Location:320 → 357
    zf-MYND; MYND finger
    pfam13857
    Location:31 → 87
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:45 → 77
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    36207123..36247290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157307.1 → XP_036013200.1  ankyrin repeat and MYND domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    sd00045
    Location:36 → 68
    ANK; ANK repeat [structural motif]
    pfam01753
    Location:311 → 348
    zf-MYND; MYND finger
    pfam12796
    Location:41 → 123
    Ank_2; Ankyrin repeats (3 copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178910.2: Suppressed sequence

    Description
    NM_178910.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TPE9.1 GenPept UniProtKB/Swiss-Prot:Q3TPE9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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