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Tep1 telomerase associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21745, updated on 18-Sep-2024

Summary

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Official Symbol
Tep1provided by MGI
Official Full Name
telomerase associated protein 1provided by MGI
Primary source
MGI:MGI:109573
See related
Ensembl:ENSMUSG00000006281 AllianceGenome:MGI:109573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tp1
Summary
Enables telomerase RNA binding activity. Contributes to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Part of telomerase holoenzyme complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human TEP1 (telomerase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 17.7), colon adult (RPKM 17.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Tep1 in Genome Data Viewer
Location:
14 C1; 14 26.26 cM
Exon count:
55
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51061513..51108036, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50824059..50870579, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E753 Neighboring gene ribonuclease P RNA component H1 Neighboring gene poly (ADP-ribose) polymerase family, member 2 Neighboring gene predicted gene, 52116 Neighboring gene STARR-positive B cell enhancer ABC_E8557 Neighboring gene predicted gene, 26782 Neighboring gene kelch-like 33 Neighboring gene Apex1 promoter region Neighboring gene O-sialoglycoprotein endopeptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Liu Y, et al. Mol Cell Biol, 2000 Nov. PMID 11027287, Free PMC Article
  2. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Nakayama J, et al. Cell, 1997 Mar 21. PMID 9118230
  3. The cytosolic chaperonin subunit TRiC-P5 begins to be expressed at the two-cell stage in mouse embryos. Sévigny G, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488101
  4. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Raval-Fernandes S, et al. Cancer Res, 2005 Oct 1. PMID 16204055
  5. The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. Kickhoefer VA, et al. J Cell Biol, 2001 Jan 8. PMID 11149928, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91078

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to telomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to telomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within telomere maintenance via telomerase IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
telomerase protein component 1
Names
p240
p80 homolog
p80 telomerase homolog
telomerase protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009351.2 → NP_033377.1  telomerase protein component 1

    See identical proteins and their annotated locations for NP_033377.1

    Status: VALIDATED

    Source sequence(s)
    BC082996, U86137
    Consensus CDS
    CCDS36907.1
    UniProtKB/Swiss-Prot
    P97499
    UniProtKB/TrEMBL
    Q5XKB2
    Related
    ENSMUSP00000006444.8, ENSMUST00000006444.9
    Conserved Domains (8) summary
    COG2319
    Location:1806 → 2198
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:1979 → 2273
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05386
    Location:1 → 29
    TEP1_N; TEP1 N-terminal domain
    pfam05729
    Location:1171 → 1346
    NACHT; NACHT domain
    pfam05731
    Location:230 → 685
    TROVE; TROVE domain
    pfam13271
    Location:917 → 1017
    DUF4062; Domain of unknown function (DUF4062)
    sd00039
    Location:1769 → 1804
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2534 → 2602
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51061513..51108036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247719.2 → XP_030103579.1  telomerase protein component 1 isoform X1

    Conserved Domains (4) summary
    pfam05386
    Location:1 → 29
    TEP1_N; TEP1 N-terminal domain
    pfam05729
    Location:1171 → 1346
    NACHT; NACHT domain
    pfam05731
    Location:230 → 685
    TROVE; TROVE domain
    pfam13271
    Location:909 → 1017
    DUF4062; Domain of unknown function (DUF4062)

RNA

  1. XR_004938374.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97499.1 GenPept UniProtKB/Swiss-Prot:P97499

Gene LinkOut

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