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Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 [ Mus musculus (house mouse) ]

Gene ID: 217378, updated on 28-Oct-2024

Summary

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Official Symbol
Dnajc27provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C27provided by MGI
Primary source
MGI:MGI:2443036
See related
Ensembl:ENSMUSG00000020657 AllianceGenome:MGI:2443036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbj; Rabj; C330021A05Rik
Summary
Enables GTPase activity. Involved in positive regulation of ERK1 and ERK2 cascade. Located in nucleus. Orthologous to human DNAJC27 (DnaJ heat shock protein family (Hsp40) member C27). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 12.8), cerebellum adult (RPKM 9.3) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc27 in Genome Data Viewer
Location:
12 A1.1; 12 1.99 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4132569..4174140)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4082569..4124140)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Pomc promoter region Neighboring gene STARR-positive B cell enhancer mm9_chr12:3959806-3960107 Neighboring gene STARR-positive B cell enhancer mm9_chr12:3981365-3981666 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3982390-3982573 Neighboring gene pro-opiomelanocortin-alpha Neighboring gene EFR3 homolog B Neighboring gene STARR-seq mESC enhancer starr_31433 Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene adenylate cyclase 3 Neighboring gene predicted gene, 53749 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene centromere protein O Neighboring gene ubiquitin associated protein 2-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. Chen T, et al. Cancer Cell, 2014 May 12. PMID 24746703
  2. RJLs: a new family of Ras-related GTP-binding proteins. Nepomuceno-Silva JL, et al. Gene, 2004 Mar 3. PMID 14980719
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily C member 27
Names
DnaJ (Hsp40) homolog, subfamily C, member 27
Rab-related GTP-binding protein
rab and DnaJ domain containing
rab and DnaJ domain-containing protein
NP_694722.2
XP_006515115.1
XP_006515116.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153082.4 → NP_694722.2  dnaJ homolog subfamily C member 27

    See identical proteins and their annotated locations for NP_694722.2

    Status: VALIDATED

    Source sequence(s)
    CB247441, CT572999
    Consensus CDS
    CCDS25786.1
    UniProtKB/Swiss-Prot
    Q8BX00, Q8CFP6, Q923I0
    Related
    ENSMUSP00000020986.8, ENSMUST00000020986.15
    Conserved Domains (2) summary
    cd06257
    Location:217 → 264
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd04119
    Location:17 → 184
    RJL; Rab GTPase family J-like (RabJ-like)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4132569..4174140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515053.5 → XP_006515116.1  dnaJ homolog subfamily C member 27 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:17 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006515052.3 → XP_006515115.1  dnaJ homolog subfamily C member 27 isoform X1

    Conserved Domains (2) summary
    cd06257
    Location:242 → 289
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd04119
    Location:17 → 209
    RJL; Rab GTPase family J-like (RabJ-like)

RNA

  1. XR_004937483.1 RNA Sequence

  2. XR_004937484.1 RNA Sequence

  3. XR_872399.3 RNA Sequence

  4. XR_381181.3 RNA Sequence

  5. XR_381182.3 RNA Sequence

  6. XR_381183.4 RNA Sequence

  7. XR_381184.3 RNA Sequence

  8. XR_003950028.2 RNA Sequence

  9. XR_003950031.2 RNA Sequence

  10. XR_003950029.2 RNA Sequence

  11. XR_003950030.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFP6.1 GenPept UniProtKB/Swiss-Prot:Q8CFP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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