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Arl5c ADP-ribosylation factor-like 5C [ Mus musculus (house mouse) ]

Gene ID: 217151, updated on 28-Oct-2024

Summary

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Official Symbol
Arl5cprovided by MGI
Official Full Name
ADP-ribosylation factor-like 5Cprovided by MGI
Primary source
MGI:MGI:3028577
See related
Ensembl:ENSMUSG00000038352 AllianceGenome:MGI:3028577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arl12
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in ileum; immune system; male reproductive gland or organ; and midbrain. Orthologous to human ARL5C (ADP ribosylation factor like GTPase 5C). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in thymus adult (RPKM 71.3), spleen adult (RPKM 13.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Arl5c in Genome Data Viewer
Location:
11 D; 11 61.47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97880404..97887109, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97989575..97996285, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene plexin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3012 Neighboring gene STARR-positive B cell enhancer ABC_E5273 Neighboring gene nuclear encoded tRNA cysteine 55 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-positive B cell enhancer ABC_E9372

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC73657

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 5C
Names
ADP-ribosylation factor-like 12
ADP-ribosylation factor-like 5C protein
ADP-ribosylation factor-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207231.1 → NP_997114.1  ADP-ribosylation factor-like protein 5C

    See identical proteins and their annotated locations for NP_997114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    BC065791
    Consensus CDS
    CCDS25334.1
    UniProtKB/Swiss-Prot
    Q3TBK5, Q6P068
    Related
    ENSMUSP00000037214.10, ENSMUST00000042971.16
    Conserved Domains (2) summary
    cd04153
    Location:3 → 172
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases
    COG1100
    Location:18 → 138
    Gem1; GTPase SAR1 family domain [General function prediction only]

RNA

  1. NR_152188.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC065791

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97880404..97887109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248941.4 → XP_011247243.1  ADP-ribosylation factor-like protein 5C isoform X4

    UniProtKB/TrEMBL
    A2A541
    Conserved Domains (1) summary
    cl38936
    Location:3 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_011248939.4 → XP_011247241.1  ADP-ribosylation factor-like protein 5C isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:3 → 120
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_036156589.1 → XP_036012482.1  ADP-ribosylation factor-like protein 5C isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:3 → 144
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_030245868.2 → XP_030101728.1  ADP-ribosylation factor-like protein 5C isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:3 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P068.1 GenPept UniProtKB/Swiss-Prot:Q6P068

Gene LinkOut

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