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Unc45b unc-45 myosin chaperone B [ Mus musculus (house mouse) ]

Gene ID: 217012, updated on 2-Nov-2024

Summary

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Official Symbol
Unc45bprovided by MGI
Official Full Name
unc-45 myosin chaperone Bprovided by MGI
Primary source
MGI:MGI:2443377
See related
Ensembl:ENSMUSG00000018845 AllianceGenome:MGI:2443377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cmya4; Unc45; UNC-45B; D230041A13Rik
Summary
Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Located in cytosol. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and soleus. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to human UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 41.6), mammary gland adult (RPKM 6.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Unc45b in Genome Data Viewer
Location:
11 C; 11 50.3 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82802112..82834284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82911253..82943406)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 8 Neighboring gene notchless homolog 1 Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5 Neighboring gene SET domain-containing protein 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke. Nicholls P, et al. FEBS Lett, 2014 Nov 3. PMID 25240199
  2. Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Bird JE, et al. Proc Natl Acad Sci U S A, 2014 Aug 26. PMID 25114250, Free PMC Article
  3. Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. Srikakulam R, et al. PLoS One, 2008 May 14. PMID 18478096, Free PMC Article
  4. Unc45 activates Hsp90-dependent folding of the myosin motor domain. Liu L, et al. J Biol Chem, 2008 May 9. PMID 18326487, Free PMC Article
  5. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. Price MG, et al. J Cell Sci, 2002 Nov 1. PMID 12356907

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 
  • Transgenic (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91090

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lens development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in A band IEA
Inferred from Electronic Annotation
more info
  
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein unc-45 homolog B
Names
cardiomyopathy associated 4
striated muscle UNC45
unc-45 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415076.1 → NP_001402005.1  protein unc-45 homolog B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603745

  2. NM_178680.5 → NP_848795.3  protein unc-45 homolog B isoform 1

    See identical proteins and their annotated locations for NP_848795.3

    Status: VALIDATED

    Source sequence(s)
    AL603745
    Consensus CDS
    CCDS36251.1
    UniProtKB/Swiss-Prot
    Q5XG72, Q8BHC5, Q8BWK3, Q8CGY6
    Related
    ENSMUSP00000018989.8, ENSMUST00000018989.14
    Conserved Domains (5) summary
    cd00020
    Location:716 → 831
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:6 → 34
    TPR; TPR repeat [structural motif]
    pfam11701
    Location:344 → 489
    UNC45-central; Myosin-binding striated muscle assembly central
    pfam13414
    Location:5 → 73
    TPR_11; TPR repeat
    sd00043
    Location:752 → 786
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82802112..82834284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGY6.1 GenPept UniProtKB/Swiss-Prot:Q8CGY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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