FABP3 fatty acid binding protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FABP3provided by HGNC
Official Full Name: fatty acid binding protein 3provided by HGNC
Primary source: HGNC:HGNC:3557
See related: Ensembl:ENSG00000121769 MIM:134651; AllianceGenome:HGNC:3557
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MDGI; FABP11; H-FABP; M-FABP; O-FABP
Summary: The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression: Biased expression in heart (RPKM 311.6), brain (RPKM 22.8) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 1p35.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (31359588..31373076, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (31211868..31225340, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (31838100..31845923, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty acid-binding protein-3 and renal function decline in patients with chronic coronary syndrome.
Title: Fatty acid-binding protein-3 and renal function decline in patients with chronic coronary syndrome.
Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19.
Title: Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19.
Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure.
Title: Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure.
Anti bacterial function of secreted human FABP3.
Title: Anti bacterial function of secreted human FABP3.
Plasma Galectin-3 and H-FABP correlate with poor physical performance in patients with congestive heart failure.
Title: Plasma Galectin-3 and H-FABP correlate with poor physical performance in patients with congestive heart failure.
Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity.
Title: Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity.
Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction.
Title: Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction.
Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
Title: Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
FABP3 overexpression promotes vascular fibrosis in Takayasu's arteritis by enhancing fatty acid oxidation in aorta adventitial fibroblasts.
Title: FABP3 overexpression promotes vascular fibrosis in Takayasu's arteritis by enhancing fatty acid oxidation in aorta adventitial fibroblasts.
Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina.
Title: Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fatty acid binding protein 3 (FABP3) in peptide-treated PBMCs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables oleic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular lipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in phospholipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-chain fatty acid import into cell	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of phospholipid biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in regulation of fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, heart

Names: epididymis secretory sperm binding protein; fatty acid binding protein 11; fatty acid binding protein 3, muscle and heart; heart-type fatty acid-binding protein; mammary-derived growth inhibitor; muscle fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047049.1 RefSeqGene

Range

5208..13031

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001320996.2 → NP_001307925.1 fatty acid-binding protein, heart isoform 1

Status: REVIEWED

Source sequence(s)

AL451070, BF576953, BI752278, BP194697, CN283506

UniProtKB/TrEMBL

Q6IBD7, S4R371

Conserved Domains (1) summary

pfam00061
Location:6 → 143

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_004102.5 → NP_004093.1 fatty acid-binding protein, heart isoform 2

See identical proteins and their annotated locations for NP_004093.1

Status: REVIEWED

Source sequence(s)

AL451070, BC007021

Consensus CDS

CCDS342.1

UniProtKB/Swiss-Prot

B2RAB6, P05413, Q5VV93, Q99957

UniProtKB/TrEMBL

A0A384MDY5, Q6IBD7, S4R371

Related

ENSP00000362817.2, ENST00000373713.7

Conserved Domains (1) summary

cd19466
Location:4 → 131

FABP3; fatty acid binding protein 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

31359588..31373076 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011541007.4 → XP_011539309.1 fatty acid-binding protein, heart isoform X1

See identical proteins and their annotated locations for XP_011539309.1

UniProtKB/TrEMBL

S4R371

Conserved Domains (1) summary

cl10502
Location:4 → 116

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family