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Evi2b ecotropic viral integration site 2b [ Mus musculus (house mouse) ]

Gene ID: 216984, updated on 2-Nov-2024

Summary

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Official Symbol
Evi2bprovided by MGI
Official Full Name
ecotropic viral integration site 2bprovided by MGI
Primary source
MGI:MGI:1890682
See related
Ensembl:ENSMUSG00000093938 AllianceGenome:MGI:1890682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Evi2; Evi-2
Summary
Involved in several processes, including myeloid cell development; positive regulation of neutrophil differentiation; and regulation of stem cell division. Predicted to be located in membrane. Is expressed in several structures, including Harderian gland; alimentary system; hemolymphoid system; integumental system; and reproductive system. Orthologous to human EVI2B (ecotropic viral integration site 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 20.2), thymus adult (RPKM 15.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Evi2b in Genome Data Viewer
Location:
11 B5; 11 46.8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79404211..79414588, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79513385..79523762, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene STARR-seq mESC enhancer starr_30120 Neighboring gene expressed sequence AU040972 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2 Neighboring gene ecotropic viral integration site 2a Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II) Neighboring gene predicted gene, 23293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evi-2, a common integration site involved in murine myeloid leukemogenesis. Buchberg AM, et al. Mol Cell Biol, 1990 Sep. PMID 2167436, Free PMC Article
  2. EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors. Zjablovskaja P, et al. Cell Death Differ, 2017 Apr. PMID 28186500, Free PMC Article
  3. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. Venturin M, et al. Ann Hum Genet, 2005 Sep. PMID 16138909
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Evi2

Readthrough gene: Evi2, Included gene: Evi2a

Homology

Clone Names

  • MGC28913

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in myeloid cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neutrophil differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein EVI2B
Names
EVI-2B
ecotropic viral integration site 2B protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077496.1 → NP_001070964.1  protein EVI2B precursor

    See identical proteins and their annotated locations for NP_001070964.1

    Status: VALIDATED

    Source sequence(s)
    AK039968, AL591174, BY196178
    Consensus CDS
    CCDS25121.1
    UniProtKB/Swiss-Prot
    Q3U1A3, Q8VD58
    Related
    ENSMUSP00000136153.2, ENSMUST00000179322.2
    Conserved Domains (1) summary
    PRK13335
    Location:32 → 169
    PRK13335; superantigen-like protein; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79404211..79414588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD58.1 GenPept UniProtKB/Swiss-Prot:Q8VD58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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