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Camta2 calmodulin binding transcription activator 2 [ Mus musculus (house mouse) ]

Gene ID: 216874, updated on 18-Sep-2024

Summary

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Official Symbol
Camta2provided by MGI
Official Full Name
calmodulin binding transcription activator 2provided by MGI
Primary source
MGI:MGI:2135957
See related
Ensembl:ENSMUSG00000040712 AllianceGenome:MGI:2135957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0909; Kiaa0909-hp
Summary
Enables sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; foregut; male reproductive gland or organ; and urinary system. Orthologous to human CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 27.2), duodenum adult (RPKM 25.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Camta2 in Genome Data Viewer
Location:
11 B3; 11 43.21 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70560288..70578966, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70669463..70688145, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3969 Neighboring gene profilin 1 Neighboring gene enolase 3, beta muscle Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene sperm associated antigen 7 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene kinesin family member 1C Neighboring gene microRNA 6925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Long C, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049392, Free PMC Article
  2. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Song K, et al. Cell, 2006 May 5. PMID 16678093
  3. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Darlington TM, et al. Genes Brain Behav, 2016 Jun. PMID 27063791, Free PMC Article
  4. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Watters JW, et al. Genomics, 2001 Apr 15. PMID 11318612
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calmodulin-binding transcription activator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190376.1 → NP_001177305.1  calmodulin-binding transcription activator 2 isoform 2

    See identical proteins and their annotated locations for NP_001177305.1

    Status: VALIDATED

    Source sequence(s)
    AK169118, AL596117, BB856280, BC056395
    Consensus CDS
    CCDS56788.1
    UniProtKB/Swiss-Prot
    Q80Y50
    Related
    ENSMUSP00000104184.2, ENSMUST00000108544.8
    Conserved Domains (5) summary
    smart01076
    Location:34 → 150
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:713 → 811
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:537 → 616
    TIG; IPT/TIG domain
    pfam13637
    Location:713 → 777
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:712 → 755
    ANK; ANK repeat [structural motif]

  2. NM_001190378.1 → NP_001177307.1  calmodulin-binding transcription activator 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596117
    Consensus CDS
    CCDS56787.1
    UniProtKB/TrEMBL
    B0QZH4
    Related
    ENSMUSP00000113847.2, ENSMUST00000119120.2
    Conserved Domains (4) summary
    smart01076
    Location:34 → 150
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:712 → 755
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:537 → 616
    TIG; IPT/TIG domain
    pfam12796
    Location:717 → 809
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001190379.1 → NP_001177308.1  calmodulin-binding transcription activator 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK169118, AL596117, BB856280
    Consensus CDS
    CCDS56786.1
    UniProtKB/Swiss-Prot
    Q80Y50
    Related
    ENSMUSP00000104185.3, ENSMUST00000108545.9
    Conserved Domains (4) summary
    sd00045
    Location:688 → 731
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:513 → 592
    TIG; IPT/TIG domain
    pfam12796
    Location:693 → 785
    Ank_2; Ankyrin repeats (3 copies)
    cl04295
    Location:34 → 126
    CG-1; CG-1 domain

  4. NM_001364103.1 → NP_001351032.1  calmodulin-binding transcription activator 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596117
    Conserved Domains (4) summary
    cd00204
    Location:753 → 851
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:752 → 795
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:577 → 656
    TIG; IPT/TIG domain
    cl04295
    Location:98 → 190
    CG-1; CG-1 domain

  5. NM_178116.4 → NP_835217.1  calmodulin-binding transcription activator 2 isoform 1

    See identical proteins and their annotated locations for NP_835217.1

    Status: VALIDATED

    Source sequence(s)
    AK169118, AL596117, BB856280, BC049133
    Consensus CDS
    CCDS24963.1
    UniProtKB/Swiss-Prot
    B0QZH5, Q3TFK0, Q5SX54, Q5SX68, Q6PHS5, Q80TP1, Q80Y50, Q8R0D9, Q8R2N5
    Related
    ENSMUSP00000043792.8, ENSMUST00000036299.14
    Conserved Domains (5) summary
    smart01076
    Location:34 → 155
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:718 → 816
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:542 → 621
    TIG; IPT/TIG domain
    pfam13637
    Location:718 → 782
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:717 → 760
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70560288..70578966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532919.5 → XP_006532982.1  calmodulin-binding transcription activator 2 isoform X2

    See identical proteins and their annotated locations for XP_006532982.1

    Conserved Domains (4) summary
    smart01076
    Location:98 → 214
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:776 → 819
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:601 → 680
    TIG; IPT/TIG domain
    pfam12796
    Location:781 → 875
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006532924.4 → XP_006532987.1  calmodulin-binding transcription activator 2 isoform X6

    See identical proteins and their annotated locations for XP_006532987.1

    UniProtKB/TrEMBL
    B0QZH6
    Related
    ENSMUSP00000113667.2, ENSMUST00000120261.8
    Conserved Domains (4) summary
    sd00045
    Location:688 → 731
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:513 → 592
    TIG; IPT/TIG domain
    pfam12796
    Location:693 → 787
    Ank_2; Ankyrin repeats (3 copies)
    cl04295
    Location:34 → 126
    CG-1; CG-1 domain

  3. XM_030245830.2 → XP_030101690.1  calmodulin-binding transcription activator 2 isoform X7

    Conserved Domains (3) summary
    sd00045
    Location:525 → 568
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:350 → 429
    TIG; IPT/TIG domain
    pfam12796
    Location:530 → 624
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006532918.5 → XP_006532981.1  calmodulin-binding transcription activator 2 isoform X1

    See identical proteins and their annotated locations for XP_006532981.1

    Conserved Domains (4) summary
    smart01076
    Location:98 → 219
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:781 → 824
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:606 → 685
    TIG; IPT/TIG domain
    pfam12796
    Location:786 → 880
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030245829.2 → XP_030101689.1  calmodulin-binding transcription activator 2 isoform X4

    Conserved Domains (4) summary
    smart01076
    Location:98 → 214
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:776 → 819
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:601 → 680
    TIG; IPT/TIG domain
    pfam12796
    Location:781 → 875
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_030245831.2 → XP_030101691.1  calmodulin-binding transcription activator 2 isoform X8

    Related
    ENSMUST00000125687.2
    Conserved Domains (3) summary
    sd00045
    Location:525 → 568
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:350 → 429
    TIG; IPT/TIG domain
    pfam12796
    Location:530 → 624
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_006532920.5 → XP_006532983.1  calmodulin-binding transcription activator 2 isoform X3

    See identical proteins and their annotated locations for XP_006532983.1

    Conserved Domains (4) summary
    smart01076
    Location:98 → 219
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:781 → 824
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:606 → 685
    TIG; IPT/TIG domain
    pfam12796
    Location:786 → 880
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_006532923.5 → XP_006532986.1  calmodulin-binding transcription activator 2 isoform X5

    See identical proteins and their annotated locations for XP_006532986.1

    Conserved Domains (4) summary
    sd00045
    Location:752 → 795
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:577 → 656
    TIG; IPT/TIG domain
    pfam12796
    Location:757 → 851
    Ank_2; Ankyrin repeats (3 copies)
    cl04295
    Location:98 → 190
    CG-1; CG-1 domain

RNA

  1. XR_001779953.3 RNA Sequence

    Related
    ENSMUST00000145823.8

  2. XR_879581.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y50.1 GenPept UniProtKB/Swiss-Prot:Q80Y50

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