Nlgn2 neuroligin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlgn2provided by MGI
Official Full Name: neuroligin 2provided by MGI
Primary source: MGI:MGI:2681835
See related: Ensembl:ENSMUSG00000051790 AllianceGenome:MGI:2681835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NL2; NLG2
Summary: Enables cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of signal transduction; and synapse organization. Acts upstream of or within several processes, including protein localization to cell surface; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in synapse. Is active in several cellular components, including dopaminergic synapse; glycinergic synapse; and postsynaptic specialization membrane. Is expressed in brain; brainstem; cerebral cortex; and hippocampus. Used to study schizophrenia. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 38.5), CNS E14 (RPKM 36.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.89 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69713949..69728610, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69823123..69837784, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.
Title: Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.
Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.
Title: Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.
Neuroligin-2 controls the establishment of fast GABAergic transmission in adult-born granule cells.
Title: Neuroligin-2 controls the establishment of fast GABAergic transmission in adult-born granule cells.
The gamma-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction.
Title: The γ-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction.
Altered theta and beta oscillatory synchrony in a genetic mouse model of pathological anxiety.
Title: Altered theta and beta oscillatory synchrony in a genetic mouse model of pathological anxiety.
Aberrant mPFC GABAergic synaptic transmission and fear behavior in neuroligin-2 R215H knock-in mice.
Title: Aberrant mPFC GABAergic synaptic transmission and fear behavior in neuroligin-2 R215H knock-in mice.
Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry.
Title: Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry.
Neuroligin-2 Determines Inhibitory Synaptic Transmission in the Lateral Septum to Optimize Stress-Induced Neuronal Activation and Avoidance Behavior.
Title: Neuroligin-2 Determines Inhibitory Synaptic Transmission in the Lateral Septum to Optimize Stress-Induced Neuronal Activation and Avoidance Behavior.
the essential role of LHFPL4/GARLH4 in brain functions by regulating inhibitory synapse formation as a major NL2 binding partner, is reported.
Title: Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.
This study provides a novel approach to understand the molecular basis of Fragile X syndrome by linking the dysregulated synaptic expression of NLGNs with FMRP
Title: Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurexin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in gephyrin clustering involved in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gephyrin clustering involved in postsynaptic density assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gephyrin clustering involved in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in insulin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in jump response	ISO Inferred from Sequence Orthology more info
involved_in jump response	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neuron cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neurotransmitter-gated ion channel clustering	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neurotransmitter-gated ion channel clustering	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neurotransmitter-gated ion channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to synapse	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of t-SNARE clustering	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of t-SNARE clustering	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic specialization assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic specialization assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in synapse organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in terminal button organization	ISO Inferred from Sequence Orthology more info
involved_in terminal button organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in thigmotaxis	ISO Inferred from Sequence Orthology more info
involved_in thigmotaxis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IC Inferred by Curator more info	PubMed
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in inhibitory synapse	IC Inferred by Curator more info	PubMed
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in ribbon synapse	IEA Inferred from Electronic Annotation more info
located_in ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuroligin-2

Names: ortholog of human and rat neuroligin 2 NLGN2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364137.1 → NP_001351066.1 neuroligin-2 precursor

Status: VALIDATED

Source sequence(s)

AK136883, AL603707

Consensus CDS

CCDS24914.1

UniProtKB/Swiss-Prot

Q5F288, Q69ZK9

Related

ENSMUSP00000104274.3, ENSMUST00000108634.9

Conserved Domains (1) summary

pfam00135
Location:42 → 601

COesterase; Carboxylesterase family
NM_198862.2 → NP_942562.2 neuroligin-2 precursor

See identical proteins and their annotated locations for NP_942562.2

Status: VALIDATED

Source sequence(s)

AK173159, BC056478, BE952199

Consensus CDS

CCDS24914.1

UniProtKB/Swiss-Prot

Q5F288, Q69ZK9

Related

ENSMUSP00000053097.4, ENSMUST00000056484.10

Conserved Domains (1) summary

pfam00135
Location:42 → 601

COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69713949..69728610 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532902.5 → XP_006532965.1 neuroligin-2 isoform X1

Conserved Domains (1) summary

pfam00135
Location:42 → 584

COesterase; Carboxylesterase family