U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tcte1 t-complex-associated testis expressed 1 [ Mus musculus (house mouse) ]

Gene ID: 21645, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tcte1provided by MGI
Official Full Name
t-complex-associated testis expressed 1provided by MGI
Primary source
MGI:MGI:98640
See related
Ensembl:ENSMUSG00000023949 AllianceGenome:MGI:98640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcte-1; D17Sil1
Summary
Involved in flagellated sperm motility. Located in sperm flagellum. Used to study male infertility. Orthologous to human TCTE1 (t-complex-associated-testis-expressed 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 114.1), cerebellum adult (RPKM 9.0) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tcte1 in Genome Data Viewer
Location:
17 B3; 17 22.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45834360..45853605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45523434..45542679)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene STARR-seq mESC enhancer starr_42624 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45625569-45626099 Neighboring gene STARR-seq mESC enhancer starr_42626 Neighboring gene STARR-positive B cell enhancer ABC_E4215 Neighboring gene STARR-positive B cell enhancer ABC_E9052 Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene transmembrane protein 151B Neighboring gene STARR-positive B cell enhancer ABC_E7533 Neighboring gene STARR-positive B cell enhancer ABC_E961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45695258-45695367 Neighboring gene STARR-positive B cell enhancer ABC_E10954 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Neighboring gene solute carrier family 35, member B2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility. Olszewska M, et al. Hum Reprod Open, 2024. PMID 38650655, Free PMC Article
  2. Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. Bibbins KB, et al. Genomics, 1989 Jul. PMID 2767684
  3. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. Morohoshi A, et al. PLoS Genet, 2020 Jan. PMID 31961863, Free PMC Article
  4. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630322, Free PMC Article
  5. Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island. Rappold GA, et al. EMBO J, 1987 Jul. PMID 3653077, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mouse TCTE1 is testis-enriched in its expression, with its mRNA appearing in early round spermatids and protein localized to the flagellum
    Title: TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dynein regulatory complex subunit 5
Names
T-complex-associated testis-expressed protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013688.3 → NP_038716.2  dynein regulatory complex subunit 5

    See identical proteins and their annotated locations for NP_038716.2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS37629.1
    UniProtKB/Swiss-Prot
    A6H639, Q62294
    Related
    ENSMUSP00000109175.2, ENSMUST00000113547.2
    Conserved Domains (3) summary
    cd00116
    Location:177 → 487
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:307 → 333
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:238 → 278
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45834360..45853605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H639.1 GenPept UniProtKB/Swiss-Prot:A6H639

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools