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Mfsd4b1 major facilitator superfamily domain containing 4B1 [ Mus musculus (house mouse) ]

Gene ID: 215929, updated on 2-Nov-2024

Summary

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Official Symbol
Mfsd4b1provided by MGI
Official Full Name
major facilitator superfamily domain containing 4B1provided by MGI
Primary source
MGI:MGI:2143575
See related
Ensembl:ENSMUSG00000038522 AllianceGenome:MGI:2143575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naglt1a
Summary
Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. Is expressed in urinary system. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 31.8), liver adult (RPKM 11.3) and 1 other tissue See more
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Genomic context

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See Mfsd4b1 in Genome Data Viewer
Location:
10 B1; 10 21.43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39877569..39901264, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40001573..40025268, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 4B3, pseudogene Neighboring gene neutrophil immunoglobulin-like receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E5125 Neighboring gene major facilitator superfamily domain containing 4B5 Neighboring gene STARR-seq mESC enhancer starr_26408 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 10 Neighboring gene STARR-seq mESC enhancer starr_26410 Neighboring gene predicted gene, 25613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:39873206-39873472 Neighboring gene STARR-positive B cell enhancer ABC_E11435 Neighboring gene predicted gene, 31992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC25869

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
sodium-dependent glucose transporter 1A
Names
major facilitator superfamily domain-containing protein 4B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144821.4 → NP_659070.2  sodium-dependent glucose transporter 1A

    See identical proteins and their annotated locations for NP_659070.2

    Status: VALIDATED

    Source sequence(s)
    AC168279
    Consensus CDS
    CCDS35884.2
    UniProtKB/Swiss-Prot
    Q8VCV9
    Related
    ENSMUSP00000128324.3, ENSMUST00000163705.3
    Conserved Domains (2) summary
    cd06174
    Location:1 → 404
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK03699
    Location:12 → 422
    PRK03699; putative transporter; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39877569..39901264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512696.5 → XP_006512759.1  sodium-dependent glucose transporter 1A isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:1 → 339
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCV9.2 GenPept UniProtKB/Swiss-Prot:Q8VCV9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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