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Ccdc92 coiled-coil domain containing 92 [ Mus musculus (house mouse) ]

Gene ID: 215707, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc92provided by MGI
Official Full Name
coiled-coil domain containing 92provided by MGI
Primary source
MGI:MGI:106485
See related
Ensembl:ENSMUSG00000037979 AllianceGenome:MGI:106485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Bwg0834e
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in innate immune response. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in centriole. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and sensory organ. Orthologous to human CCDC92 (coiled-coil domain containing 92). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 212.4), cerebellum adult (RPKM 45.1) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc92 in Genome Data Viewer
Location:
5 G1.1; 5 63.85 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124911482..124939261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124834432..124862499, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:125079413-125079714 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2 Neighboring gene dynein, axonemal, heavy chain 10 Neighboring gene zinc finger protein 664 Neighboring gene predicted gene, 32449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease. Zuo F, et al. Metabolism, 2024 Jan. PMID 37952690
  2. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. Ren L, et al. iScience, 2023 Jan 20. PMID 36594018, Free PMC Article
  3. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38387

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418046.1 → NP_001404975.1  coiled-coil domain-containing protein 92

    Status: VALIDATED

    Source sequence(s)
    AC164649
    UniProtKB/Swiss-Prot
    Q8VDN4

  2. NM_144819.3 → NP_659068.1  coiled-coil domain-containing protein 92

    See identical proteins and their annotated locations for NP_659068.1

    Status: VALIDATED

    Source sequence(s)
    AC164649
    Consensus CDS
    CCDS19681.1
    UniProtKB/Swiss-Prot
    Q8VDN4
    Related
    ENSMUSP00000038075.8, ENSMUST00000036206.14
    Conserved Domains (2) summary
    TIGR04523
    Location:5 → 151
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam14916
    Location:7 → 63
    CCDC92; Coiled-coil domain of unknown function

RNA

  1. NR_184680.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164649

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124911482..124939261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320799.1 → XP_017176288.1  coiled-coil domain-containing protein 92 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDN4.1 GenPept UniProtKB/Swiss-Prot:Q8VDN4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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