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Sec22c SEC22 homolog C, vesicle trafficking protein [ Mus musculus (house mouse) ]

Gene ID: 215474, updated on 2-Nov-2024

Summary

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Official Symbol
Sec22cprovided by MGI
Official Full Name
SEC22 homolog C, vesicle trafficking proteinprovided by MGI
Primary source
MGI:MGI:2447871
See related
Ensembl:ENSMUSG00000061536 AllianceGenome:MGI:2447871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec22l3; 4932412K21; C530046H07; 5930407I15Rik
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human SEC22C (SEC22 homolog C, vesicle trafficking protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 5.4), duodenum adult (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sec22c in Genome Data Viewer
Location:
9 F4; 9 72.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121509111..121534614, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121680045..121705548, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene lysozyme-like 4 Neighboring gene lysozyme-like 4, opposite strand Neighboring gene STARR-seq mESC enhancer starr_25538 Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10592 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121591571-121591680 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121606658-121606959 Neighboring gene STARR-positive B cell enhancer ABC_E11426 Neighboring gene STARR-positive B cell enhancer ABC_E1400 Neighboring gene STARR-positive B cell enhancer ABC_E10593 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 2 Neighboring gene natural killer tumor recognition sequence Neighboring gene RIKEN cDNA E530011L22 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Rohacek AM, et al. Dev Cell, 2017 Nov 6. PMID 29107558, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicle-trafficking protein SEC22c
Names
SEC22 vesicle trafficking protein homolog C
SEC22 vesicle trafficking protein-like 3
SEC22 vesicle trafficking protein-like C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164562.1 → NP_001158034.1  vesicle-trafficking protein SEC22c

    See identical proteins and their annotated locations for NP_001158034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC159810, AK044249, BC046289, CJ247427
    Consensus CDS
    CCDS23634.1
    UniProtKB/Swiss-Prot
    Q8BMH4, Q8BXT9, Q8C0R8
    Related
    ENSMUSP00000107185.3, ENSMUST00000111560.10
    Conserved Domains (1) summary
    cd14824
    Location:5 → 123
    Longin; longin domain

  2. NM_178677.4 → NP_848792.2  vesicle-trafficking protein SEC22c

    See identical proteins and their annotated locations for NP_848792.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC159810, BB661643, BC046289, CJ247427
    Consensus CDS
    CCDS23634.1
    UniProtKB/Swiss-Prot
    Q8BMH4, Q8BXT9, Q8C0R8
    Related
    ENSMUSP00000077628.5, ENSMUST00000078547.12
    Conserved Domains (1) summary
    cd14824
    Location:5 → 123
    Longin; longin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121509111..121534614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512043.5 → XP_006512106.1  vesicle-trafficking protein SEC22c isoform X1

    See identical proteins and their annotated locations for XP_006512106.1

    UniProtKB/Swiss-Prot
    Q8BMH4, Q8BXT9, Q8C0R8
    Conserved Domains (1) summary
    cd14824
    Location:5 → 123
    Longin; longin domain

  2. XM_006512042.5 → XP_006512105.1  vesicle-trafficking protein SEC22c isoform X1

    See identical proteins and their annotated locations for XP_006512105.1

    UniProtKB/Swiss-Prot
    Q8BMH4, Q8BXT9, Q8C0R8
    Conserved Domains (1) summary
    cd14824
    Location:5 → 123
    Longin; longin domain

  3. XM_030244233.2 → XP_030100093.1  vesicle-trafficking protein SEC22c isoform X3

  4. XM_006512044.5 → XP_006512107.1  vesicle-trafficking protein SEC22c isoform X2

    Conserved Domains (1) summary
    cd14824
    Location:5 → 123
    Longin; longin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXT9.1 GenPept UniProtKB/Swiss-Prot:Q8BXT9

Gene LinkOut

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