Scgn secretagogin, EF-hand calcium binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scgnprovided by MGI
Official Full Name: secretagogin, EF-hand calcium binding proteinprovided by MGI
Primary source: MGI:MGI:2384873
See related: Ensembl:ENSMUSG00000021337 AllianceGenome:MGI:2384873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Predicted to be located in cytoplasmic vesicle; extracellular region; and membrane. Predicted to be active in several cellular components, including cytosol; dendrite; and terminal bouton. Is expressed in brain; genitourinary system; heart; pancreas; and stomach. Orthologous to human SCGN (secretagogin, EF-hand calcium binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 4.4), large intestine adult (RPKM 1.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 10.01 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (24137439..24175310, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (23953456..23991327, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Cytoskeletal Transport Protein, Secretagogin, Is Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice.
Title: The Cytoskeletal Transport Protein, Secretagogin, Is Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice.
Secretagogin is a Ca(2+)-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies.
Title: Secretagogin is a Ca(2+)-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies.
Rabies virus infection is associated with alterations in the expression of parvalbumin and secretagogin in mice brain.
Title: Rabies virus infection is associated with alterations in the expression of parvalbumin and secretagogin in mice brain.
Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.
Title: Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice.
Secretagogin marks amygdaloid PKCdelta interneurons and modulates NMDA receptor availability.
Title: Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability.
Secretagogin expression in the mouse olfactory bulb under sensory impairments.
Title: Secretagogin expression in the mouse olfactory bulb under sensory impairments.
The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1.
Title: The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1.
Secretagogin physically binds alpha-synuclein and rescues it from detrimental fibrillation.
Title: Secretagogin Binding Prevents α-Synuclein Fibrillation.
Secretagogin prevents Pdx1 degradation through proteasome inactivation. Thas, secretagogin controls a transcriptional program required for beta cell specification.
Title: Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.
Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration.
Title: Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secretagogin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145399.1 → NP_663374.1 secretagogin

See identical proteins and their annotated locations for NP_663374.1

Status: PROVISIONAL

Source sequence(s)

BC016093

Consensus CDS

CCDS26375.1

UniProtKB/Swiss-Prot

Q91WD9

Related

ENSMUSP00000021770.8, ENSMUST00000021770.8

Conserved Domains (2) summary

cd00051
Location:109 → 179

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:111 → 178

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

24137439..24175310 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516638.4 → XP_006516701.1 secretagogin isoform X1

Conserved Domains (2) summary

cd15902
Location:17 → 45

EFh_HEF; EF-hand motif [structural motif]

cl23634
Location:17 → 236

EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family