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Dis3l DIS3 like exosome 3'-5' exoribonuclease [ Mus musculus (house mouse) ]

Gene ID: 213550, updated on 28-Oct-2024

Summary

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Official Symbol
Dis3lprovided by MGI
Official Full Name
DIS3 like exosome 3'-5' exoribonucleaseprovided by MGI
Primary source
MGI:MGI:2143272
See related
Ensembl:ENSMUSG00000032396 AllianceGenome:MGI:2143272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable enzyme binding activity and exoribonuclease II activity. Predicted to be involved in RNA processing; mRNA catabolic process; and rRNA catabolic process. Predicted to be located in centrosome; cytosol; and plasma membrane. Predicted to be part of cytoplasmic exosome (RNase complex). Orthologous to human DIS3L (DIS3 like exosome 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 24.6), cerebellum adult (RPKM 6.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dis3l in Genome Data Viewer
Location:
9 C; 9 34.62 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64214038..64248707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64306756..64341403, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8856 Neighboring gene STARR-positive B cell enhancer ABC_E2293 Neighboring gene STARR-seq mESC enhancer starr_24425 Neighboring gene STARR-seq mESC enhancer starr_24427 Neighboring gene STARR-positive B cell enhancer ABC_E6754 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene STARR-seq mESC enhancer starr_24428 Neighboring gene predicted gene, 24289 Neighboring gene timeless interacting protein Neighboring gene STARR-seq mESC enhancer starr_24432 Neighboring gene STARR-seq mESC enhancer starr_24433 Neighboring gene multiple EGF-like-domains 11 Neighboring gene STARR-seq mESC enhancer starr_24435 Neighboring gene STARR-positive B cell enhancer mm9_chr9:64519558-64519858 Neighboring gene STARR-positive B cell enhancer ABC_E9767 Neighboring gene predicted gene, 36311 Neighboring gene RAB11A, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility. Wang X, et al. Reprod Biol, 2024 Sep. PMID 38875746
  2. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility.
    Title: Loss of DIS3L in the initial segment is dispensable for sperm maturation in the epididymis and male fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 3'-5'-RNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables exoribonuclease II activity ISO
Inferred from Sequence Orthology
more info
  
enables exoribonuclease II activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DIS3-like exonuclease 1
Names
DIS3 mitotic control homolog-like
NP_001001295.2
NP_001171255.1
NP_766107.1
XP_006511045.1
XP_011241002.1
XP_030100066.1
XP_036010677.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001295.2 → NP_001001295.2  DIS3-like exonuclease 1 isoform 1

    See identical proteins and their annotated locations for NP_001001295.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC056939, BM900123, BY497083, CJ157436
    Consensus CDS
    CCDS52832.1
    UniProtKB/Swiss-Prot
    Q69Z56, Q8C0S1
    Related
    ENSMUSP00000129772.3, ENSMUST00000168844.9
    Conserved Domains (3) summary
    COG0557
    Location:265 → 899
    VacB; Exoribonuclease R [Transcription]
    cd09862
    Location:11 → 188
    PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    pfam17215
    Location:875 → 958
    Rrp44_S1; S1 domain

  2. NM_001177784.1 → NP_001171255.1  DIS3-like exonuclease 1 isoform 2

    See identical proteins and their annotated locations for NP_001171255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC135358, AK077031, BM900123, BY497083
    Consensus CDS
    CCDS23280.1
    UniProtKB/Swiss-Prot
    Q8C0S1
    Related
    ENSMUSP00000113503.2, ENSMUST00000120760.8
    Conserved Domains (3) summary
    COG0557
    Location:182 → 816
    VacB; Exoribonuclease R [Transcription]
    pfam17215
    Location:792 → 875
    Rrp44_S1; S1 domain
    cl28905
    Location:1 → 105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  3. NM_172519.3 → NP_766107.1  DIS3-like exonuclease 1 isoform 2

    See identical proteins and their annotated locations for NP_766107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK029974, BM900123, BY497083
    Consensus CDS
    CCDS23280.1
    UniProtKB/Swiss-Prot
    Q8C0S1
    Related
    ENSMUSP00000109522.2, ENSMUST00000113890.2
    Conserved Domains (3) summary
    COG0557
    Location:182 → 816
    VacB; Exoribonuclease R [Transcription]
    pfam17215
    Location:792 → 875
    Rrp44_S1; S1 domain
    cl28905
    Location:1 → 105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64214038..64248707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244206.2 → XP_030100066.1  DIS3-like exonuclease 1 isoform X1

    Conserved Domains (3) summary
    COG0557
    Location:131 → 765
    VacB; Exoribonuclease R [Transcription]
    pfam17215
    Location:741 → 824
    Rrp44_S1; S1 domain
    cl28905
    Location:1 → 54
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  2. XM_011242700.3 → XP_011241002.1  DIS3-like exonuclease 1 isoform X1

    See identical proteins and their annotated locations for XP_011241002.1

    Conserved Domains (3) summary
    COG0557
    Location:131 → 765
    VacB; Exoribonuclease R [Transcription]
    pfam17215
    Location:741 → 824
    Rrp44_S1; S1 domain
    cl28905
    Location:1 → 54
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  3. XM_036154784.1 → XP_036010677.1  DIS3-like exonuclease 1 isoform X3

    Conserved Domains (2) summary
    COG0557
    Location:33 → 602
    VacB; Exoribonuclease R [Transcription]
    pfam17215
    Location:578 → 661
    Rrp44_S1; S1 domain

  4. XM_006510982.5 → XP_006511045.1  DIS3-like exonuclease 1 isoform X2

    See identical proteins and their annotated locations for XP_006511045.1

    UniProtKB/Swiss-Prot
    Q8C0S1
    Conserved Domains (3) summary
    COG0557
    Location:182 → 816
    VacB; Exoribonuclease R [Transcription]
    pfam17215
    Location:792 → 875
    Rrp44_S1; S1 domain
    cl28905
    Location:1 → 105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0S1.2 GenPept UniProtKB/Swiss-Prot:Q8C0S1

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