U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Klhdc8a kelch domain containing 8A [ Mus musculus (house mouse) ]

Gene ID: 213417, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Klhdc8aprovided by MGI
Official Full Name
kelch domain containing 8Aprovided by MGI
Primary source
MGI:MGI:2442630
See related
Ensembl:ENSMUSG00000042115 AllianceGenome:MGI:2442630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630065K24Rik
Summary
Is expressed in adrenal cortex; central nervous system; metanephros; neural retina; and trigeminal nerve. Orthologous to human KLHDC8A (kelch domain containing 8A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in adrenal adult (RPKM 84.1), cerebellum adult (RPKM 7.1) and 2 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Klhdc8a in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132226352..132236216)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132298490..132307357)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02242 Neighboring gene predicted gene 29630 Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241 Neighboring gene STARR-positive B cell enhancer ABC_E2009 Neighboring gene STARR-seq mESC enhancer starr_02251 Neighboring gene NUAK family, SNF1-like kinase, 2 Neighboring gene predicted gene, 30744 Neighboring gene VISTA enhancer mm505 Neighboring gene RIKEN cDNA F730311O21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7749 Neighboring gene STARR-positive B cell enhancer ABC_E11087

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Ota M, et al. Development, 2008 Dec. PMID 19004856
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC19056

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kelch domain-containing protein 8A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417652.1 → NP_001404581.1  kelch domain-containing protein 8A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160545

  2. NM_144810.6 → NP_659059.1  kelch domain-containing protein 8A isoform 1

    See identical proteins and their annotated locations for NP_659059.1

    Status: VALIDATED

    Source sequence(s)
    AC160545
    Consensus CDS
    CCDS35706.1
    UniProtKB/Swiss-Prot
    Q91XA8
    UniProtKB/TrEMBL
    Q8C939
    Related
    ENSMUSP00000038297.5, ENSMUST00000046071.5
    Conserved Domains (2) summary
    PHA03098
    Location:5 → 209
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:21 → 65
    Kelch; KELCH repeat [structural motif]

RNA

  1. NR_184552.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC160545

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132226352..132236216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529354.5 → XP_006529417.1  kelch domain-containing protein 8A isoform X1

    See identical proteins and their annotated locations for XP_006529417.1

    UniProtKB/Swiss-Prot
    Q91XA8
    UniProtKB/TrEMBL
    Q8C939
    Conserved Domains (2) summary
    PHA03098
    Location:5 → 209
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:21 → 65
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XA8.1 GenPept UniProtKB/Swiss-Prot:Q91XA8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools