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Aox2 aldehyde oxidase 2 [ Mus musculus (house mouse) ]

Gene ID: 213043, updated on 18-Sep-2024

Summary

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Official Symbol
Aox2provided by MGI
Official Full Name
aldehyde oxidase 2provided by MGI
Primary source
MGI:MGI:3529596
See related
Ensembl:ENSMUSG00000079554 AllianceGenome:MGI:3529596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aoh3; Aox3l1
Summary
Predicted to enable aldehyde oxidase activity. Predicted to be located in cytoplasm. Is expressed in nervous system; nose; and olfactory epithelium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Aox2 in Genome Data Viewer
Location:
1 C1.3; 1 29.0 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58317485..58418423)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58278326..58379264)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 3 Neighboring gene predicted gene, 24548 Neighboring gene aldehyde oxidase 4 Neighboring gene predicted gene 15759 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58450605-58450792 Neighboring gene predicted gene, 53481 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene basic leucine zipper and W2 domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases. Cerqueira NM, et al. J Biol Inorg Chem, 2015 Mar. PMID 25287365
  2. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, et al. J Biol Chem, 2004 Nov 26. PMID 15383531
  3. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, et al. Cell Mol Life Sci, 2013 May. PMID 23263164, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
    Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
  2. selectively expressed in Bowman's glands of the olfactory mucosa
    Title: The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables flavin adenine dinucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molybdopterin cofactor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aldehyde oxidase 2
Names
aldehyde oxidase 3-like 1
aldehyde oxidase homolog 3
aldehyde oxidase-like protein 3
azaheterocycle hydroxylase 2
NP_001008419.1
XP_017175142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008419.2 → NP_001008419.1  aldehyde oxidase 2

    See identical proteins and their annotated locations for NP_001008419.1

    Status: VALIDATED

    Source sequence(s)
    AC121091, AC163498
    Consensus CDS
    CCDS35576.1
    UniProtKB/Swiss-Prot
    B9EKC6, Q5SGK3
    Related
    ENSMUSP00000110006.2, ENSMUST00000114366.3
    Conserved Domains (7) summary
    TIGR02969
    Location:10 → 1344
    mam_aldehyde_ox; aldehyde oxidase
    smart01008
    Location:604 → 706
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    cd00207
    Location:11 → 84
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
    pfam00941
    Location:241 → 421
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:92 → 163
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:721 → 1251
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:428 → 532
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58317485..58418423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319653.3 → XP_017175142.1  aldehyde oxidase 2 isoform X1

    Conserved Domains (1) summary
    TIGR02969
    Location:10 → 1329
    mam_aldehyde_ox; aldehyde oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SGK3.2 GenPept UniProtKB/Swiss-Prot:Q5SGK3

Gene LinkOut

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