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Mfsd4a major facilitator superfamily domain containing 4A [ Mus musculus (house mouse) ]

Gene ID: 213006, updated on 2-Nov-2024

Summary

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Official Symbol
Mfsd4aprovided by MGI
Official Full Name
major facilitator superfamily domain containing 4Aprovided by MGI
Primary source
MGI:MGI:2442786
See related
Ensembl:ENSMUSG00000059149 AllianceGenome:MGI:2442786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mfsd4; A230072B04; A930031D07Rik
Summary
Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD4A (major facilitator superfamily domain containing 4A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 40.5), adrenal adult (RPKM 15.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Mfsd4a in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131947543..131997400, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132022806..132069658, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene ELK4, member of ETS oncogene family Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998691-133998892 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998935-133999044 Neighboring gene predicted gene, 37120

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Kerr N, et al. Mol Cell Neurosci, 2010 Jun. PMID 20304071, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 4A
Names
major facilitator superfamily domain containing 4
major facilitator superfamily domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114662.1 → NP_001108134.1  major facilitator superfamily domain-containing protein 4A isoform b

    See identical proteins and their annotated locations for NP_001108134.1

    Status: VALIDATED

    Source sequence(s)
    AC107837, AI642828, AK048692, AK085484, AK162495
    Consensus CDS
    CCDS48357.1
    UniProtKB/Swiss-Prot
    Q6PDC8, Q8C3M3, Q8C816, Q8CAF5
    UniProtKB/TrEMBL
    E0CX35
    Related
    ENSMUSP00000125558.2, ENSMUST00000159038.8
    Conserved Domains (2) summary
    cd06174
    Location:298 → 480
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:22 → 442
    MFS_1; Major Facilitator Superfamily

  2. NM_172510.4 → NP_766098.2  major facilitator superfamily domain-containing protein 4A isoform a

    See identical proteins and their annotated locations for NP_766098.2

    Status: VALIDATED

    Source sequence(s)
    AK048692, AK162495
    Consensus CDS
    CCDS15280.2
    UniProtKB/TrEMBL
    F8WIG8
    Related
    ENSMUSP00000107989.3, ENSMUST00000112370.9
    Conserved Domains (1) summary
    cd17453
    Location:18 → 479
    MFS_MFSD4A; Major facilitator superfamily domain-containing protein 4A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131947543..131997400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529345.5 → XP_006529408.1  major facilitator superfamily domain-containing protein 4A isoform X2

    See identical proteins and their annotated locations for XP_006529408.1

    UniProtKB/Swiss-Prot
    Q6PDC8
    Conserved Domains (1) summary
    cl28910
    Location:1 → 257
    MFS; Major Facilitator Superfamily

  2. XM_030252744.2 → XP_030108604.1  major facilitator superfamily domain-containing protein 4A isoform X1

    UniProtKB/TrEMBL
    F8WIG8
    Related
    ENSMUSP00000116282.3, ENSMUST00000144548.9
    Conserved Domains (1) summary
    cd17453
    Location:18 → 479
    MFS_MFSD4A; Major facilitator superfamily domain-containing protein 4A

  3. XM_017319650.3 → XP_017175139.1  major facilitator superfamily domain-containing protein 4A isoform X2

    UniProtKB/Swiss-Prot
    Q6PDC8
    Conserved Domains (1) summary
    cl28910
    Location:1 → 257
    MFS; Major Facilitator Superfamily

  4. XM_006529344.5 → XP_006529407.1  major facilitator superfamily domain-containing protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006529407.1

    UniProtKB/TrEMBL
    F8WIG8
    Related
    ENSMUSP00000116706.2, ENSMUST00000126927.8
    Conserved Domains (1) summary
    cd17453
    Location:18 → 479
    MFS_MFSD4A; Major facilitator superfamily domain-containing protein 4A

  5. XM_030252750.2 → XP_030108610.1  major facilitator superfamily domain-containing protein 4A isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:1 → 257
    MFS; Major Facilitator Superfamily

RNA

  1. XR_001783717.3 RNA Sequence

  2. XR_001783716.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDC8.2 GenPept UniProtKB/Swiss-Prot:Q6PDC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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