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Pgghg protein glucosylgalactosylhydroxylysine glucosidase [ Mus musculus (house mouse) ]

Gene ID: 212974, updated on 2-Nov-2024

Summary

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Official Symbol
Pgghgprovided by MGI
Official Full Name
protein glucosylgalactosylhydroxylysine glucosidaseprovided by MGI
Primary source
MGI:MGI:2444047
See related
Ensembl:ENSMUSG00000062031 AllianceGenome:MGI:2444047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Athl1; 5730511L01Rik
Summary
Predicted to enable protein-glucosylgalactosylhydroxylysine glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including nervous system and retina. Orthologous to human PGGHG (protein-glucosylgalactosylhydroxylysine glucosidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 26.5), adrenal adult (RPKM 24.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pgghg in Genome Data Viewer
Location:
7 F5; 7 86.16 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140521304..140527577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140941391..140947664)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8220 Neighboring gene cDNA sequence BC023486 Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E2853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148127673-148127984 Neighboring gene interferon induced transmembrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_20461 Neighboring gene interferon induced transmembrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC28193

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-glucosylgalactosylhydroxylysine glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glucosylgalactosylhydroxylysine glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-glucosylgalactosylhydroxylysine glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein-glucosylgalactosylhydroxylysine glucosidase
Names
ATH1, acid trehalase-like 1
acid trehalase-like protein 1
mFLJ00228 protein
NP_663362.2
XP_017177593.1
XP_017177594.1
XP_017177595.1
XP_030098196.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145387.5 → NP_663362.2  protein-glucosylgalactosylhydroxylysine glucosidase

    See identical proteins and their annotated locations for NP_663362.2

    Status: VALIDATED

    Source sequence(s)
    AC162287, BC056953
    Consensus CDS
    CCDS21992.1
    UniProtKB/Swiss-Prot
    Q571E9, Q8BP56, Q8R585
    Related
    ENSMUSP00000078372.5, ENSMUST00000079403.11
    Conserved Domains (2) summary
    COG1554
    Location:5 → 645
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:291 → 605
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain

RNA

  1. NR_153832.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162287
    Related
    ENSMUST00000164337.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140521304..140527577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322105.1 → XP_017177594.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X2

    Conserved Domains (1) summary
    COG1554
    Location:189 → 612
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

  2. XM_030242336.1 → XP_030098196.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X3

    Conserved Domains (1) summary
    COG1554
    Location:189 → 608
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

  3. XM_017322104.1 → XP_017177593.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1

    Related
    ENSMUST00000169736.8
    Conserved Domains (1) summary
    COG1554
    Location:5 → 649
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

  4. XM_017322106.1 → XP_017177595.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X4

    Conserved Domains (1) summary
    COG1554
    Location:5 → 422
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]

RNA

  1. XR_004934054.1 RNA Sequence

  2. XR_001785517.1 RNA Sequence

  3. XR_003946433.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP56.1 GenPept UniProtKB/Swiss-Prot:Q8BP56

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