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Chpt1 choline phosphotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 212862, updated on 2-Nov-2024

Summary

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Official Symbol
Chpt1provided by MGI
Official Full Name
choline phosphotransferase 1provided by MGI
Primary source
MGI:MGI:2384841
See related
Ensembl:ENSMUSG00000060002 AllianceGenome:MGI:2384841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within phosphatidylcholine biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and retina. Orthologous to human CHPT1 (choline phosphotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 37.3), kidney adult (RPKM 34.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Chpt1 in Genome Data Viewer
Location:
10 C1; 10 43.93 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88305376..88339855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88469513..88503970, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2332 Neighboring gene STARR-positive B cell enhancer ABC_E11453 Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene STARR-positive B cell enhancer ABC_E5162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:87872706-87873007 Neighboring gene STARR-positive B cell enhancer ABC_E2333 Neighboring gene STARR-positive B cell enhancer ABC_E3906 Neighboring gene synaptonemal complex protein 3 Neighboring gene STARR-seq mESC enhancer starr_27496 Neighboring gene myosin binding protein C, slow-type Neighboring gene STARR-seq mESC enhancer starr_27498 Neighboring gene STARR-positive B cell enhancer ABC_E6897 Neighboring gene STARR-seq mESC enhancer starr_27500 Neighboring gene STARR-seq mESC enhancer starr_27501 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered mouse cholinephosphotransferase gene expression in kidneys of type 2 diabetic KK/TA mouse. Gohda T, et al. Metabolism, 2004 Jul. PMID 15254874
  2. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
  3. Rapid and Integrative Discovery of Retina Regulatory Molecules. Albrecht NE, et al. Cell Rep, 2018 Aug 28. PMID 30157441, Free PMC Article
  4. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. Gao L, et al. J Clin Invest, 2015 Jul 1. PMID 26098214, Free PMC Article
  5. Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Imbard A, et al. Sci Rep, 2021 Oct 26. PMID 34702858, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC28885

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables diacylglycerol cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol cholinephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables diacylglycerol cholinephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in platelet activating factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet activating factor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cholinephosphotransferase 1
Names
diabetic nephropathy-associated gene transcript 1
diacylglycerol cholinephosphotransferase 1
NP_001140162.1
NP_659056.3
XP_006513517.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146690.1 → NP_001140162.1  cholinephosphotransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AW823530, BE137041, BE650891, BY341208, CJ177670, EL958096
    Consensus CDS
    CCDS48665.1
    UniProtKB/TrEMBL
    D3YU39
    Related
    ENSMUSP00000112708.2, ENSMUST00000117440.8
    Conserved Domains (1) summary
    cl00453
    Location:25 → 337
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. NM_144807.3 → NP_659056.3  cholinephosphotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_659056.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 3' coding region and 3' UTR versus variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC125486, AK032497, CJ177670
    Consensus CDS
    CCDS24112.1
    UniProtKB/Swiss-Prot
    Q6SXV1, Q8C025, Q8K0H2, Q91W91
    Related
    ENSMUSP00000020253.9, ENSMUST00000020253.15
    Conserved Domains (1) summary
    cl00453
    Location:25 → 337
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RNA

  1. NR_027477.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 3' coding region, compared to variant 1. Uncertainty about the protein-coding capacity of the transcript exists because the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW823530, BE650891, BY341208, CJ177670, EL958096

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88305376..88339855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513454.3 → XP_006513517.1  cholinephosphotransferase 1 isoform X1

    Conserved Domains (1) summary
    cl00453
    Location:25 → 213
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RNA

  1. XR_004936148.1 RNA Sequence

  2. XR_003948646.2 RNA Sequence

  3. XR_003948645.2 RNA Sequence

  4. XR_003948644.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C025.1 GenPept UniProtKB/Swiss-Prot:Q8C025

Gene LinkOut

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