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Arl14ep ADP-ribosylation factor-like 14 effector protein [ Mus musculus (house mouse) ]

Gene ID: 212772, updated on 18-Sep-2024

Summary

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Official Symbol
Arl14epprovided by MGI
Official Full Name
ADP-ribosylation factor-like 14 effector proteinprovided by MGI
Primary source
MGI:MGI:1926020
See related
Ensembl:ENSMUSG00000027122 AllianceGenome:MGI:1926020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARF7EP; 2700007P21Rik; 4930448O08Rik
Summary
Predicted to be located in several cellular components, including cytosol; focal adhesion; and nuclear lumen. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in cerebral cortex ventricular layer; olfactory cortex ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human ARL14EP (ADP ribosylation factor like GTPase 14 effector protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.0), limb E14.5 (RPKM 6.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Arl14ep in Genome Data Viewer
Location:
2 E3; 2 55.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (106792874..106804742, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (106962529..106974397, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54139 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 39902 Neighboring gene STARR-seq mESC enhancer starr_05332 Neighboring gene STARR-seq mESC enhancer starr_05333 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene follicle stimulating hormone beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ARL14 effector protein
Names
ARF7 effector protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025102.2 → NP_001020273.1  ARL14 effector protein

    See identical proteins and their annotated locations for NP_001020273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    BX649348, BX890640
    Consensus CDS
    CCDS16503.1
    UniProtKB/Swiss-Prot
    Q7TPE6, Q8BIX3, Q9CZS0
    Related
    ENSMUSP00000028536.7, ENSMUST00000028536.13
    Conserved Domains (1) summary
    pfam14949
    Location:145 → 248
    ARF7EP_C; ARF7 effector protein C-terminus

  2. NM_001362864.1 → NP_001349793.1  ARL14 effector protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    BX649348, BX890640
    Consensus CDS
    CCDS16503.1
    UniProtKB/Swiss-Prot
    Q7TPE6, Q8BIX3, Q9CZS0
    Conserved Domains (1) summary
    pfam14949
    Location:145 → 248
    ARF7EP_C; ARF7 effector protein C-terminus

  3. NM_001362865.1 → NP_001349794.1  ARL14 effector protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    BX649348, BX890640
    Consensus CDS
    CCDS16503.1
    UniProtKB/Swiss-Prot
    Q7TPE6, Q8BIX3, Q9CZS0
    Conserved Domains (1) summary
    pfam14949
    Location:145 → 248
    ARF7EP_C; ARF7 effector protein C-terminus

  4. NM_173750.2 → NP_776111.1  ARL14 effector protein

    See identical proteins and their annotated locations for NP_776111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AA407700, AI552408, AK076781, BB595211, BE648222, BY651964, CA327681, CK623335
    Consensus CDS
    CCDS16503.1
    UniProtKB/Swiss-Prot
    Q7TPE6, Q8BIX3, Q9CZS0
    Related
    ENSMUSP00000091409.4, ENSMUST00000093883.4
    Conserved Domains (1) summary
    pfam14949
    Location:145 → 248
    ARF7EP_C; ARF7 effector protein C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    106792874..106804742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIX3.1 GenPept UniProtKB/Swiss-Prot:Q8BIX3

Gene LinkOut

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