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N4bp3 NEDD4 binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 212706, updated on 28-Oct-2024

Summary

Official Symbol
N4bp3provided by MGI
Official Full Name
NEDD4 binding protein 3provided by MGI
Primary source
MGI:MGI:2442218
See related
Ensembl:ENSMUSG00000001053 AllianceGenome:MGI:2442218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330016O10Rik
Summary
Predicted to be involved in nervous system development. Predicted to act upstream of with a positive effect on innate immune response. Located in cytoplasmic vesicle. Is expressed in several structures, including central nervous system; eye; gut; lung; and reproductive system. Orthologous to human N4BP3 (NEDD4 binding protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 10.8), ovary adult (RPKM 7.6) and 26 other tissues See more
Orthologs
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Genomic context

See N4bp3 in Genome Data Viewer
Location:
11 B1.3; 11 31.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51533908..51541664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51643081..51651073, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene STARR-positive B cell enhancer ABC_E255 Neighboring gene NHP2 ribonucleoprotein Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene STARR-positive B cell enhancer ABC_E8400 Neighboring gene STARR-seq mESC enhancer starr_29422 Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene predicted gene, 30058 Neighboring gene STARR-seq mESC enhancer starr_29425 Neighboring gene STARR-seq mESC enhancer starr_29426 Neighboring gene STARR-positive B cell enhancer ABC_E6981 Neighboring gene STARR-seq mESC enhancer starr_29427 Neighboring gene trafficking protein particle complex 2B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7136

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418169.1NP_001405098.1  NEDD4-binding protein 3

    Status: VALIDATED

    Source sequence(s)
    AL645602
    UniProtKB/Swiss-Prot
    A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
  2. NM_145974.4NP_666086.2  NEDD4-binding protein 3

    See identical proteins and their annotated locations for NP_666086.2

    Status: VALIDATED

    Source sequence(s)
    AL645602
    Consensus CDS
    CCDS24657.1
    UniProtKB/Swiss-Prot
    A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
    Related
    ENSMUSP00000001080.10, ENSMUST00000001080.16
    Conserved Domains (2) summary
    pfam05262
    Location:256439
    Borrelia_P83; Borrelia P83/100 protein
    pfam06818
    Location:361518
    Fez1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51533908..51541664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245757.1XP_030101617.1  NEDD4-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
    Conserved Domains (2) summary
    pfam05262
    Location:256439
    Borrelia_P83; Borrelia P83/100 protein
    pfam06818
    Location:361518
    Fez1
  2. XM_006532765.5XP_006532828.1  NEDD4-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006532828.1

    UniProtKB/Swiss-Prot
    A2AA64, Q3TDC7, Q3URT6, Q7TNR2, Q8C7U1, Q922W0, Q99J06
    Conserved Domains (2) summary
    pfam05262
    Location:256439
    Borrelia_P83; Borrelia P83/100 protein
    pfam06818
    Location:361518
    Fez1