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Fam193b family with sequence similarity 193, member B [ Mus musculus (house mouse) ]

Gene ID: 212483, updated on 28-Oct-2024

Summary

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Official Symbol
Fam193bprovided by MGI
Official Full Name
family with sequence similarity 193, member Bprovided by MGI
Primary source
MGI:MGI:2385851
See related
Ensembl:ENSMUSG00000021495 AllianceGenome:MGI:2385851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRIZIO; Kiaa1931
Summary
Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human FAM193B (family with sequence similarity 193 member B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 74.0), adrenal adult (RPKM 37.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fam193b in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55687129..55718920, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55539316..55571120, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10796 Neighboring gene docking protein 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:55637802-55638169 Neighboring gene DEAD box helicase 41 Neighboring gene predicted gene, 46416 Neighboring gene predicted gene, 31364 Neighboring gene transmembrane p24 trafficking protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). Picchione F, et al. Carcinogenesis, 2011 Apr. PMID 21177767, Free PMC Article
  2. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, et al. EMBO J, 2016 May 17. PMID 26951610, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC29235, MGC38018, MGC39032

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein FAM193B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408645.1 → NP_001395574.1  protein FAM193B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126408
    UniProtKB/Swiss-Prot
    Q3U2K0, Q69Z63, Q8K1B4, Q8VCA1

  2. NM_001408646.1 → NP_001395575.1  protein FAM193B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126408
    UniProtKB/TrEMBL
    A0A286YE27
    Related
    ENSMUSP00000153687.3, ENSMUST00000225240.3

  3. NM_001408647.1 → NP_001395576.1  protein FAM193B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126408

  4. NM_001408648.1 → NP_001395577.1  protein FAM193B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126408

  5. NM_001408649.1 → NP_001395578.1  protein FAM193B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126408

  6. NM_001408650.1 → NP_001395579.1  protein FAM193B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126408

  7. NM_001408651.1 → NP_001395580.1  protein FAM193B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126408

  8. NM_001408652.1 → NP_001395581.1  protein FAM193B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC126408

  9. NM_001408653.1 → NP_001395582.1  protein FAM193B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC126408

  10. NM_001408654.1 → NP_001395583.1  protein FAM193B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126408

  11. NM_001408655.1 → NP_001395584.1  protein FAM193B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126408

  12. NM_001408656.1 → NP_001395585.1  protein FAM193B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126408

  13. NM_001408657.1 → NP_001395586.1  protein FAM193B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126408

  14. NM_001408658.1 → NP_001395587.1  protein FAM193B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126408

  15. NM_145382.5 → NP_663357.2  protein FAM193B isoform 1

    See identical proteins and their annotated locations for NP_663357.2

    Status: VALIDATED

    Source sequence(s)
    AC126408
    Consensus CDS
    CCDS36678.1
    UniProtKB/Swiss-Prot
    Q3U2K0
    Related
    ENSMUSP00000021957.7, ENSMUST00000021957.8
    Conserved Domains (2) summary
    PTZ00449
    Location:568 → 720
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15914
    Location:723 → 773
    FAM193_C; FAM193 family C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55687129..55718920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157964.1 → XP_036013857.1  protein FAM193B isoform X7

    Conserved Domains (2) summary
    pfam15914
    Location:643 → 693
    FAM193_C; FAM193 family C-terminal
    NF033839
    Location:305 → 637
    PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

  2. XM_017315477.2 → XP_017170966.1  protein FAM193B isoform X8

    Conserved Domains (3) summary
    PTZ00449
    Location:388 → 540
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15914
    Location:543 → 593
    FAM193_C; FAM193 family C-terminal
    NF033839
    Location:231 → 537
    PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

  3. XM_017315475.2 → XP_017170964.1  protein FAM193B isoform X6

    Conserved Domains (2) summary
    PTZ00449
    Location:536 → 688
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15914
    Location:691 → 741
    FAM193_C; FAM193 family C-terminal

  4. XM_006517195.3 → XP_006517258.1  protein FAM193B isoform X2

    Conserved Domains (3) summary
    PTZ00449
    Location:615 → 767
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15914
    Location:770 → 820
    FAM193_C; FAM193 family C-terminal
    pfam17061
    Location:142 → 251
    PARM

  5. XM_036157970.1 → XP_036013863.1  protein FAM193B isoform X11

    Conserved Domains (2) summary
    PTZ00449
    Location:233 → 385
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15914
    Location:388 → 438
    FAM193_C; FAM193 family C-terminal

RNA

  1. XR_001780770.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U2K0.2 GenPept UniProtKB/Swiss-Prot:Q3U2K0

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