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Lactb2 lactamase, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 212442, updated on 2-Nov-2024

Summary

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Official Symbol
Lactb2provided by MGI
Official Full Name
lactamase, beta 2provided by MGI
Primary source
MGI:MGI:2442551
See related
Ensembl:ENSMUSG00000025937 AllianceGenome:MGI:2442551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgi-83; E430032H21Rik
Summary
Predicted to enable RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Located in mitochondrion. Is expressed in brain ventricular layer; liver lobe; lung; renal cortex; and submandibular gland primordium. Orthologous to human LACTB2 (lactamase beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 64.2), liver adult (RPKM 44.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Lactb2 in Genome Data Viewer
Location:
1 A3; 1 4.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13695069..13730749, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13625893..13660583, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00273 Neighboring gene predicted gene, 39600 Neighboring gene STARR-seq mESC enhancer starr_00275 Neighboring gene STARR-seq mESC enhancer starr_00276 Neighboring gene STARR-seq mESC enhancer starr_00277 Neighboring gene STARR-seq mESC enhancer starr_00278 Neighboring gene translocating chain-associating membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_00279 Neighboring gene STARR-seq mESC enhancer starr_00283 Neighboring gene STARR-seq mESC enhancer starr_00284 Neighboring gene X-linked Kx blood group related 9 Neighboring gene predicted gene, 26273

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Sollars VE, et al. Hum Mol Genet, 2002 Oct 15. PMID 12374767
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7674

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
endoribonuclease LACTB2
Names
beta-lactamase-like protein 2
NP_001404559.1
NP_001404562.1
NP_001404563.1
NP_001404564.1
NP_001404565.1
NP_663356.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417630.1 → NP_001404559.1  endoribonuclease LACTB2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116708

  2. NM_001417633.1 → NP_001404562.1  endoribonuclease LACTB2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116708

  3. NM_001417634.1 → NP_001404563.1  endoribonuclease LACTB2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116708

  4. NM_001417635.1 → NP_001404564.1  endoribonuclease LACTB2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116708

  5. NM_001417636.1 → NP_001404565.1  endoribonuclease LACTB2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC116708

  6. NM_145381.3 → NP_663356.1  endoribonuclease LACTB2 isoform 1

    See identical proteins and their annotated locations for NP_663356.1

    Status: VALIDATED

    Source sequence(s)
    AC116708
    Consensus CDS
    CCDS14823.1
    UniProtKB/Swiss-Prot
    Q99KR3
    Related
    ENSMUSP00000027071.6, ENSMUST00000027071.7
    Conserved Domains (2) summary
    COG0491
    Location:23 → 223
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cd07722
    Location:14 → 203
    LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain

RNA

  1. NR_184544.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116708

  2. NR_184545.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116708

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    13695069..13730749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KR3.1 GenPept UniProtKB/Swiss-Prot:Q99KR3

Gene LinkOut

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