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Trim52 tripartite motif-containing 52 [ Mus musculus (house mouse) ]

Gene ID: 212085, updated on 2-Nov-2024

Summary

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Official Symbol
Trim52provided by MGI
Official Full Name
tripartite motif-containing 52provided by MGI
Primary source
MGI:MGI:3045276
See related
Ensembl:ENSMUSG00000022113 AllianceGenome:MGI:3045276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921513B05Rik
Summary
Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of NF-kappaB transcription factor activity; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human TRIM52 (tripartite motif containing 52). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 7.0) and CNS E11.5 (RPKM 0.1) See more
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Genomic context

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See Trim52 in Genome Data Viewer
Location:
14 E2.3; 14 56.16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (106343632..106373296)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (106106198..106135862)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene FSHD region gene 2 family member 4 Neighboring gene predicted gene 4775 Neighboring gene STARR-seq mESC enhancer starr_37550 Neighboring gene predicted gene, 23459 Neighboring gene predicted gene, 36107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM52 aggravated inflammation and pyroptosis in dextran sulfate sodium-induced inflammatory bowel disease through activation of the TLR4/NF-κBs pathway. Ma JP, et al. Allergol Immunopathol (Madr), 2023. PMID 36617836
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM52 aggravated inflammation and pyroptosis in dextran sulfate sodium-induced inflammatory bowel disease through activation of the TLR4/NF-kappaBs pathway.
    Title: TRIM52 aggravated inflammation and pyroptosis in dextran sulfate sodium-induced inflammatory bowel disease through activation of the TLR4/NF-κBs pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198601.3 → NP_941003.1  tripartite motif-containing 52

    See identical proteins and their annotated locations for NP_941003.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC126691, AK029521, AV266877
    Consensus CDS
    CCDS27323.1
    UniProtKB/TrEMBL
    Q8CDV4
    Related
    ENSMUSP00000022708.6, ENSMUST00000022708.7
    Conserved Domains (2) summary
    TIGR00599
    Location:3 → 211
    rad18; DNA repair protein rad18
    cd16602
    Location:16 → 48
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins

RNA

  1. NR_073203.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AC126691
    Related
    ENSMUST00000194236.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    106343632..106373296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518780.4 → XP_006518843.1  tripartite motif-containing 52 isoform X1

    See identical proteins and their annotated locations for XP_006518843.1

    UniProtKB/TrEMBL
    Q8CDV4
    Conserved Domains (2) summary
    TIGR00599
    Location:3 → 211
    rad18; DNA repair protein rad18
    cd16602
    Location:16 → 48
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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