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Vstm2a V-set and transmembrane domain containing 2A [ Mus musculus (house mouse) ]

Gene ID: 211739, updated on 2-Nov-2024

Summary

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Official Symbol
Vstm2aprovided by MGI
Official Full Name
V-set and transmembrane domain containing 2Aprovided by MGI
Primary source
MGI:MGI:2384826
See related
Ensembl:ENSMUSG00000048834 AllianceGenome:MGI:2384826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vstm2
Summary
Enables identical protein binding activity. Involved in several processes, including cellular response to BMP stimulus; positive regulation of brown fat cell differentiation; and positive regulation of white fat cell proliferation. Located in extracellular region. Is expressed in central nervous system; head mesenchyme; hindlimb mesenchyme; and jaw bone. Orthologous to human VSTM2A (V-set and transmembrane domain containing 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 13.3), frontal lobe adult (RPKM 12.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Vstm2a in Genome Data Viewer
Location:
11 A2; 11 8.89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16207742..16234551)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16257742..16284551)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12010 Neighboring gene STARR-seq mESC enhancer starr_28674 Neighboring gene STARR-seq mESC enhancer starr_28675 Neighboring gene STARR-seq mESC enhancer starr_28676 Neighboring gene STARR-seq mESC enhancer starr_28677 Neighboring gene STARR-seq mESC enhancer starr_28678 Neighboring gene STARR-seq mESC enhancer starr_28679 Neighboring gene STARR-seq mESC enhancer starr_28680 Neighboring gene STARR-seq mESC enhancer starr_28681 Neighboring gene predicted gene 12011 Neighboring gene STARR-seq mESC enhancer starr_28683 Neighboring gene STARR-seq mESC enhancer starr_28684 Neighboring gene STARR-seq mESC enhancer starr_28685 Neighboring gene STARR-seq mESC enhancer starr_28687 Neighboring gene STARR-positive B cell enhancer ABC_E11470 Neighboring gene predicted gene 12012 Neighboring gene SEC61 translocon subunit gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Control of adipogenic commitment by a STAT3-VSTM2A axis. Al Dow M, et al. Am J Physiol Endocrinol Metab, 2021 Feb 1. PMID 33196296, Free PMC Article
  2. Amplification of Adipogenic Commitment by VSTM2A. Secco B, et al. Cell Rep, 2017 Jan 3. PMID 28052263, Free PMC Article
  3. Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways. Rolfe RA, et al. BMC Genomics, 2014 Jan 20. PMID 24443808, Free PMC Article
  4. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
  5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of adipogenic commitment by a STAT3-VSTM2A axis.
    Title: Control of adipogenic commitment by a STAT3-VSTM2A axis.
  2. VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.
    Title: Amplification of Adipogenic Commitment by VSTM2A.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC38877, 9330184N17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to BMP stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of white fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of white fat cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
V-set and transmembrane domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290539.2 → NP_001277468.1  V-set and transmembrane domain-containing protein 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001277468.1

    Status: VALIDATED

    Source sequence(s)
    AK033048, AK134954, AK137363, BM963943
    UniProtKB/TrEMBL
    A0A140LHB6
    Related
    ENSMUSP00000146349.2, ENSMUST00000208926.2
    Conserved Domains (2) summary
    smart00410
    Location:33 → 148
    IG_like; Immunoglobulin like
    cl11960
    Location:31 → 138
    Ig; Immunoglobulin domain

  2. NM_001363461.1 → NP_001350390.1  V-set and transmembrane domain-containing protein 2A isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL604031
    UniProtKB/TrEMBL
    A0A140LHB6
    Conserved Domains (1) summary
    smart00410
    Location:33 → 148
    IG_like; Immunoglobulin like

  3. NM_145967.3 → NP_666079.2  V-set and transmembrane domain-containing protein 2A isoform 2 precursor

    See identical proteins and their annotated locations for NP_666079.2

    Status: VALIDATED

    Source sequence(s)
    AK033048, AK134954, BC027127
    Consensus CDS
    CCDS24441.2
    UniProtKB/Swiss-Prot
    Q8R0A6
    UniProtKB/TrEMBL
    F6Y6A6
    Related
    ENSMUSP00000105272.3, ENSMUST00000109645.9
    Conserved Domains (2) summary
    smart00410
    Location:33 → 148
    IG_like; Immunoglobulin like
    pfam07686
    Location:31 → 138
    V-set; Immunoglobulin V-set domain

RNA

  1. NR_156693.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL604031, CN530668

  2. NR_156694.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL604031

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16207742..16234551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0A6.2 GenPept UniProtKB/Swiss-Prot:Q8R0A6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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