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Exoc3 exocyst complex component 3 [ Mus musculus (house mouse) ]

Gene ID: 211446, updated on 2-Nov-2024

Summary

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Official Symbol
Exoc3provided by MGI
Official Full Name
exocyst complex component 3provided by MGI
Primary source
MGI:MGI:2443972
See related
Ensembl:ENSMUSG00000034152 AllianceGenome:MGI:2443972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec6; Sec6l1; 2810050O03Rik; E430013E20Rik
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be located in secretory granule membrane. Predicted to be part of exocyst. Predicted to be active in presynaptic membrane. Orthologous to human EXOC3 (exocyst complex component 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.0), CNS E11.5 (RPKM 9.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Exoc3 in Genome Data Viewer
Location:
13 C1; 13 40.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74317921..74358151, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74169802..74210032, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 72 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 Neighboring gene predicted gene, 41003 Neighboring gene STARR-positive B cell enhancer ABC_E8534 Neighboring gene aryl-hydrocarbon receptor repressor Neighboring gene programmed cell death 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the exocyst complex component EXOC3 promotes hemostasis and accelerates arterial thrombosis. Walsh TG, et al. Blood Adv, 2021 Feb 9. PMID 33560379, Free PMC Article
  2. Transcriptional regulation of gene expression of sec6, a component of mammalian exocyst complex at the synapse. Chin LS, et al. Brain Res Mol Brain Res, 2000 Jun 23. PMID 10925150
  3. Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. Tsuboi T, et al. J Biol Chem, 2005 Jul 8. PMID 15878854
  4. Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Mikami N, et al. Exp Anim, 2024 Jul 9. PMID 38325858, Free PMC Article
  5. Exorcising the exocyst complex. Heider MR, et al. Traffic, 2012 Jul. PMID 22420621, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice.
    Title: Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice.
  2. the exocyst complex serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane
    Title: Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 3
Names
SEC6-like 1
exocyst complex component Sec6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177333.4 → NP_796307.2  exocyst complex component 3

    See identical proteins and their annotated locations for NP_796307.2

    Status: VALIDATED

    Source sequence(s)
    AC123833, AC154839
    Consensus CDS
    CCDS26640.1
    UniProtKB/Swiss-Prot
    Q6KAR6
    UniProtKB/TrEMBL
    Q8BIT7, Q8K0E2
    Related
    ENSMUSP00000039416.6, ENSMUST00000035934.7
    Conserved Domains (1) summary
    pfam06046
    Location:187 → 743
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74317921..74358151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517191.4 → XP_006517254.1  exocyst complex component 3 isoform X1

    See identical proteins and their annotated locations for XP_006517254.1

    UniProtKB/Swiss-Prot
    Q6KAR6
    UniProtKB/TrEMBL
    Q8BIT7, Q8K0E2
    Conserved Domains (1) summary
    pfam06046
    Location:187 → 743
    Sec6; Exocyst complex component Sec6

  2. XM_006517192.3 → XP_006517255.1  exocyst complex component 3 isoform X2

    UniProtKB/TrEMBL
    Q8BIT7
    Conserved Domains (1) summary
    pfam06046
    Location:187 → 657
    Sec6; Exocyst complex component Sec6

  3. XM_017315474.3 → XP_017170963.1  exocyst complex component 3 isoform X2

    UniProtKB/TrEMBL
    Q8BIT7
    Conserved Domains (1) summary
    pfam06046
    Location:187 → 657
    Sec6; Exocyst complex component Sec6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6KAR6.2 GenPept UniProtKB/Swiss-Prot:Q6KAR6

Gene LinkOut

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