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Nckap5 NCK-associated protein 5 [ Mus musculus (house mouse) ]

Gene ID: 210356, updated on 2-Nov-2024

Summary

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Official Symbol
Nckap5provided by MGI
Official Full Name
NCK-associated protein 5provided by MGI
Primary source
MGI:MGI:2686394
See related
Ensembl:ENSMUSG00000049690 AllianceGenome:MGI:2686394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nap5; Erih1; Erih2; Gm1548; 8430408F21; D130011D22Rik; E030049G20Rik
Summary
Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be active in microtubule plus-end. Is expressed in central nervous system; lung; and sensory organ. Orthologous to human NCKAP5 (NCK associated protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 4.1), CNS E18 (RPKM 1.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Nckap5 in Genome Data Viewer
Location:
1 E3; 1 54.7 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (125841373..126758529, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (125913636..126830796, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 39 Neighboring gene predicted gene, 41943 Neighboring gene Ly6/Plaur domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02114 Neighboring gene predicted gene, 35562 Neighboring gene STARR-seq mESC enhancer starr_02115 Neighboring gene STARR-seq mESC enhancer starr_02116 Neighboring gene RIKEN cDNA 4930599A14 gene Neighboring gene STARR-seq mESC enhancer starr_02117 Neighboring gene predicted gene, 41945

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC90557

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nck-associated protein 5
Names
peripheral clock protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081756.1 → NP_001075225.1  nck-associated protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001075225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK053243, BC066095, CN700744
    Consensus CDS
    CCDS35695.1
    UniProtKB/TrEMBL
    E9QAE1, F6VHY8, Q29SA9
    Related
    ENSMUSP00000108202.2, ENSMUST00000112583.8
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  2. NM_172484.3 → NP_766072.2  nck-associated protein 5 isoform 2

    See identical proteins and their annotated locations for NP_766072.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and a protein (isoform 2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK053243, BC066095
    Consensus CDS
    CCDS48345.1
    UniProtKB/TrEMBL
    F6VHY8, Q29SA9, Q6NZK2
    Related
    ENSMUSP00000125624.2, ENSMUST00000161954.8
    Conserved Domains (2) summary
    pfam15246
    Location:1363 → 1665
    NCKAP5; Nck-associated protein 5, Peripheral clock protein
    cl23720
    Location:2 → 89
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. NM_176957.3 → NP_795931.2  nck-associated protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several segments in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK053243, BC066095, CN700744
    Consensus CDS
    CCDS48346.1
    UniProtKB/TrEMBL
    E9Q3G9, Q8C6S8
    Related
    ENSMUSP00000092192.4, ENSMUST00000094609.10
    Conserved Domains (1) summary
    pfam15246
    Location:271 → 363
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    125841373..126758529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163201.1 → XP_036019094.1  nck-associated protein 5 isoform X10

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:741 → 952
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:57 → 254
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1367 → 1669
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  2. XM_030252625.2 → XP_030108485.1  nck-associated protein 5 isoform X7

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:741 → 952
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:57 → 254
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1367 → 1669
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  3. XM_006529326.5 → XP_006529389.1  nck-associated protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006529389.1

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  4. XM_006529330.5 → XP_006529393.1  nck-associated protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006529393.1

    UniProtKB/TrEMBL
    E9QAE1, F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  5. XM_006529336.5 → XP_006529399.1  nck-associated protein 5 isoform X13

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  6. XM_006529329.5 → XP_006529392.1  nck-associated protein 5 isoform X2

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  7. XM_006529334.5 → XP_006529397.1  nck-associated protein 5 isoform X11

    See identical proteins and their annotated locations for XP_006529397.1

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  8. XM_006529325.5 → XP_006529388.1  nck-associated protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006529388.1

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  9. XM_011247963.4 → XP_011246265.1  nck-associated protein 5 isoform X16

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:839 → 1050
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:57 → 254
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1465 → 1767
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  10. XM_011247958.4 → XP_011246260.1  nck-associated protein 5 isoform X3

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:780 → 991
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:19 → 234
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1406 → 1708
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  11. XM_030252637.2 → XP_030108497.1  nck-associated protein 5 isoform X15

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Related
    ENSMUSP00000062229.9, ENSMUST00000057846.15
    Conserved Domains (3) summary
    PHA03247
    Location:673 → 884
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:3 → 186
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1299 → 1601
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  12. XM_006529332.4 → XP_006529395.1  nck-associated protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006529395.1

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:737 → 948
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:3 → 208
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1363 → 1665
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  13. XM_036163204.1 → XP_036019097.1  nck-associated protein 5 isoform X12

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:708 → 919
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:24 → 221
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1334 → 1636
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  14. XM_011247959.3 → XP_011246261.1  nck-associated protein 5 isoform X5

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:772 → 983
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:16 → 226
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1398 → 1700
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  15. XM_036163207.1 → XP_036019100.1  nck-associated protein 5 isoform X15

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:673 → 884
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:3 → 186
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1299 → 1601
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  16. XM_011247960.3 → XP_011246262.1  nck-associated protein 5 isoform X6

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:765 → 976
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:4 → 219
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1391 → 1693
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  17. XM_030252628.2 → XP_030108488.1  nck-associated protein 5 isoform X8

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:737 → 948
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:3 → 208
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15246
    Location:1363 → 1665
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  18. XM_036163206.1 → XP_036019099.1  nck-associated protein 5 isoform X14

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

  19. XM_036163199.1 → XP_036019092.1  nck-associated protein 5 isoform X9

    UniProtKB/TrEMBL
    F6VHY8, Q29SA9
    Conserved Domains (3) summary
    PHA03247
    Location:805 → 1016
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:44 → 259
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15246
    Location:1431 → 1733
    NCKAP5; Nck-associated protein 5, Peripheral clock protein

RNA

  1. XR_004941376.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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