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Lrch2 leucine-rich repeats and calponin homology (CH) domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 210297, updated on 10-Oct-2024

Summary

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Official Symbol
Lrch2provided by MGI
Official Full Name
leucine-rich repeats and calponin homology (CH) domain containing 2provided by MGI
Primary source
MGI:MGI:2147870
See related
Ensembl:ENSMUSG00000031290 AllianceGenome:MGI:2147870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1495
Summary
Is expressed in adrenal cortex; central nervous system; skeletal musculature; and urinary system. Orthologous to human LRCH2 (leucine rich repeats and calponin homology domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 6.4), whole brain E14.5 (RPKM 6.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Lrch2 in Genome Data Viewer
Location:
X F2; X 68.46 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (146253376..146337198, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (147470375..147554103, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 13 receptor, alpha 2 Neighboring gene vomeronasal 1 receptor 239, pseudogene Neighboring gene predicted gene, 25107 Neighboring gene STARR-seq mESC enhancer starr_48058 Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene predicted gene 8289

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice. Zhang Q, et al. Mol Reprod Dev, 2019 Jun. PMID 31012985
  2. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  4. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine-rich repeat and calponin homology domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081173.3 → NP_001074642.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001074642.1

    Status: VALIDATED

    Source sequence(s)
    AL671981, AL807780
    Consensus CDS
    CCDS41160.1
    UniProtKB/Swiss-Prot
    A2AMN8, Q3UMG5, Q7TNP9, Q80TC9
    UniProtKB/TrEMBL
    F6VQ19
    Related
    ENSMUSP00000108438.3, ENSMUST00000112819.9
    Conserved Domains (5) summary
    cd00116
    Location:144 → 245
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:100 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00307
    Location:652 → 759
    CH; Calponin homology (CH) domain
    pfam12799
    Location:144 → 181
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:189 → 245
    LRR_8; Leucine rich repeat

  2. NM_001356368.2 → NP_001343297.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671981, AL807780
    UniProtKB/TrEMBL
    F6VQ19
    Conserved Domains (3) summary
    smart00033
    Location:667 → 756
    CH; Calponin homology domain
    sd00033
    Location:100 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:76 → 290
    NEL; C-terminal novel E3 ligase, LRR-interacting

  3. NM_001356369.2 → NP_001343298.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671981, AL807780
    Conserved Domains (3) summary
    smart00033
    Location:501 → 590
    CH; Calponin homology domain
    sd00033
    Location:26 → 48
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:7 → 172
    NEL; C-terminal novel E3 ligase, LRR-interacting

  4. NM_001403576.1 → NP_001390505.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL671981, AL807780

  5. NM_001403578.1 → NP_001390507.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL671981, AL807780

  6. NM_001403579.1 → NP_001390508.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL671981, AL807780

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    146253376..146337198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528790.5 → XP_006528853.3  leucine-rich repeat and calponin homology domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    F6VQ19
    Conserved Domains (3) summary
    PRK15370
    Location:101 → 315
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:125 → 145
    LRR_RI; leucine-rich repeat [structural motif]
    cd21271
    Location:659 → 769
    CH_LRCH2; calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2

  2. XM_006528792.4 → XP_006528855.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    F6VQ19
    Conserved Domains (3) summary
    smart00033
    Location:566 → 655
    CH; Calponin homology domain
    COG4886
    Location:7 → 233
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:26 → 48
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMG5.2 GenPept UniProtKB/Swiss-Prot:Q3UMG5

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