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Pgbd5 piggyBac transposable element derived 5 [ Mus musculus (house mouse) ]

Gene ID: 209966, updated on 17-Aug-2024

Summary

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Official Symbol
Pgbd5provided by MGI
Official Full Name
piggyBac transposable element derived 5provided by MGI
Primary source
MGI:MGI:2429955
See related
Ensembl:ENSMUSG00000050751 AllianceGenome:MGI:2429955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900019M05Rik
Summary
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in cortex adult (RPKM 40.9), frontal lobe adult (RPKM 35.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E2; 8 72.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125095788..125161230, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124369049..124433936, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22999 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 24459 Neighboring gene STARR-seq mESC enhancer starr_23006 Neighboring gene RIKEN cDNA C330016L05 gene Neighboring gene predicted gene, 30209

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans. Pavelitz T, et al. Mob DNA, 2013 Nov 1. PMID 24180413, Free PMC Article
  2. Molecular evolutionary analysis of the widespread piggyBac transposon family and related "domesticated" sequences. Sarkar A, et al. Mol Genet Genomics, 2003 Nov. PMID 12955498
  3. Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. Isbel L, et al. PLoS Genet, 2015 Dec. PMID 26624618, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.
    Title: Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.
  2. Childhood cancer mutagenesis caused by transposase-derived PGBD5.
    Title: Childhood cancer mutagenesis caused by transposase-derived PGBD5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables transposase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transposase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in non-replicative DNA transposition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-replicative DNA transposition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transposition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
piggyBac transposable element-derived protein 5
Names
piggyBac transposase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_171824.3 → NP_741958.2  piggyBac transposable element-derived protein 5

    Status: VALIDATED

    Source sequence(s)
    AC114005, AC126930
    Consensus CDS
    CCDS22770.1
    UniProtKB/Swiss-Prot
    D3YZI9, D3Z077, E9PUA8, Q52KE6
    UniProtKB/TrEMBL
    G3UX58
    Related
    ENSMUSP00000120984.2, ENSMUST00000140012.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125095788..125161230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243379.2 → XP_030099239.1  piggyBac transposable element-derived protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A510C1L5
    Related
    ENSMUSP00000133560.2, ENSMUST00000172566.8
    Conserved Domains (1) summary
    pfam13843
    Location:20 → 386
    DDE_Tnp_1_7; Transposase IS4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YZI9.1 GenPept UniProtKB/Swiss-Prot:D3YZI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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