Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Enpp3provided by MGI
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 3provided by MGI
Primary source: MGI:MGI:2143702
See related: Ensembl:ENSMUSG00000019989 AllianceGenome:MGI:2143702
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD203c
Summary: Enables nucleoside triphosphate diphosphatase activity. Involved in several processes, including basophil activation involved in immune response; negative regulation of mast cell activation involved in immune response; and negative regulation of mast cell proliferation. Located in external side of plasma membrane. Is expressed in femur. Orthologous to human ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine adult (RPKM 19.3), duodenum adult (RPKM 14.8) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 12.26 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24649712..24712093, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24773814..24836195, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint.
Title: Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint.
In Enpp3-/- mice, ATP concentrations were increased in the intestinal lumen. Plasmacytoid dendritic cell (pDC) numbers were remarkably decreased in the small intestinal lamina propria and Peyer's patches. Intestinal pDCs of Enpp3-/- mice showed enhanced cell death.
Title: E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.
E-NPP3 decreases ATP concentration and suppresses basophil and mast cell activity.
Title: The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236320

AI876438 (e-PCR)
- UniSTS:180019

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Enpp3 (e-PCR), detects polymorphism
- UniSTS:546756

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables GTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables UTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-adenosyl)-pentaphosphatase activity	ISO Inferred from Sequence Orthology more info
enables bis(5'-adenosyl)-pentaphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables bis(5'-adenosyl)-triphosphatase activity	ISO Inferred from Sequence Orthology more info
enables bis(5'-adenosyl)-triphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISO Inferred from Sequence Orthology more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside triphosphate diphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphodiesterase I activity	ISO Inferred from Sequence Orthology more info
enables phosphodiesterase I activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in basophil activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Names: E-NPP 3; NPPase; PD-Ibeta; alkaline phosphodiesterase I; dinucleoside polyphosphatase; nucleotide diphosphatase; nucleotide pyrophosphatase; phosphodiesterase I beta; phosphodiesterase I/nucleotide pyrophosphatase 3

NP_598766.2

EC 3.1.4.1

EC 3.6.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134005.2 → NP_598766.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 3

See identical proteins and their annotated locations for NP_598766.2

Status: VALIDATED

Source sequence(s)

AK132256, BB400671

Consensus CDS

CCDS23752.1

UniProtKB/Swiss-Prot

E9QMU8, Q6DYE8

Related

ENSMUSP00000020169.8, ENSMUST00000020169.9

Conserved Domains (4) summary

smart00201
Location:50 → 93

SO; Somatomedin B -like domains

smart00477
Location:627 → 856

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:161 → 485

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:159 → 525

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

24649712..24712093 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_145372.1: Suppressed sequence

Description

NM_145372.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.