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Tmem164 transmembrane protein 164 [ Mus musculus (house mouse) ]

Gene ID: 209497, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem164provided by MGI
Official Full Name
transmembrane protein 164provided by MGI
Primary source
MGI:MGI:2148020
See related
Ensembl:ENSMUSG00000047045 AllianceGenome:MGI:2148020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F730011B02
Summary
Predicted to be involved in positive regulation of ferroptosis. Predicted to be located in membrane. Orthologous to human TMEM164 (transmembrane protein 164). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 14.6), ovary adult (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem164 in Genome Data Viewer
Location:
X F2; X 63.54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141463343..141626490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142680347..142843494)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15032 Neighboring gene regulator of G-protein signaling 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48023 Neighboring gene STARR-seq mESC enhancer starr_48024 Neighboring gene microRNA 652 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 13 Neighboring gene STARR-seq mESC enhancer starr_48025 Neighboring gene AMMECR nuclear protein 1 Neighboring gene STARR-seq mESC enhancer starr_48026 Neighboring gene retrotransposon Gag like 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice. Zhang L, et al. Nat Metab, 2023 Oct. PMID 37679556
  2. TMEM164 is a new determinant of autophagy-dependent ferroptosis. Liu J, et al. Autophagy, 2023 Mar. PMID 35947500, Free PMC Article
  3. TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD. Su Y, et al. Autoimmunity, 2024 Dec. PMID 39392409
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD.
    Title: TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD.
  2. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice.
    Title: Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice.
  3. TMEM164 is a new determinant of autophagy-dependent ferroptosis.
    Title: TMEM164 is a new determinant of autophagy-dependent ferroptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ferroptosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 164
Names
arachidonoyl ether phospholipid synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199357.1 → NP_001186286.1  transmembrane protein 164 isoform b

    See identical proteins and their annotated locations for NP_001186286.1

    Status: VALIDATED

    Source sequence(s)
    AK166488, AL731674, AL731678
    Consensus CDS
    CCDS57778.1
    UniProtKB/TrEMBL
    A2AH99
    Related
    ENSMUSP00000108510.2, ENSMUST00000112889.8
    Conserved Domains (1) summary
    pfam14808
    Location:1 → 124
    TMEM164; TMEM164 family

  2. NM_001199360.1 → NP_001186289.1  transmembrane protein 164 isoform a

    See identical proteins and their annotated locations for NP_001186289.1

    Status: VALIDATED

    Source sequence(s)
    AL731674, AL731678, BF457004, CB525724
    Consensus CDS
    CCDS30451.1
    UniProtKB/Swiss-Prot
    Q6PHN7
    UniProtKB/TrEMBL
    Q8C237
    Related
    ENSMUSP00000108517.3, ENSMUST00000112896.9
    Conserved Domains (1) summary
    pfam14808
    Location:10 → 272
    TMEM164; TMEM164 family

  3. NM_001358725.1 → NP_001345654.1  transmembrane protein 164 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL731674, AL731678, BC059043
    Consensus CDS
    CCDS57778.1
    UniProtKB/TrEMBL
    A2AH99
    Conserved Domains (1) summary
    pfam14808
    Location:1 → 124
    TMEM164; TMEM164 family

  4. NM_001358727.1 → NP_001345656.1  transmembrane protein 164 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL731674, AL731678, BC059043, CB525911
    Consensus CDS
    CCDS57778.1
    UniProtKB/TrEMBL
    A2AH99
    Conserved Domains (1) summary
    pfam14808
    Location:1 → 124
    TMEM164; TMEM164 family

  5. NM_001358728.1 → NP_001345657.1  transmembrane protein 164 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL731674, AL731678, BC059043, BU703507
    Consensus CDS
    CCDS57778.1
    UniProtKB/TrEMBL
    A2AH99
    Related
    ENSMUSP00000098759.3, ENSMUST00000101198.9
    Conserved Domains (1) summary
    pfam14808
    Location:1 → 124
    TMEM164; TMEM164 family

  6. NM_177592.4 → NP_808260.2  transmembrane protein 164 isoform a

    See identical proteins and their annotated locations for NP_808260.2

    Status: VALIDATED

    Source sequence(s)
    AL731678, BC056470, BC059043
    Consensus CDS
    CCDS30451.1
    UniProtKB/Swiss-Prot
    Q6PHN7
    UniProtKB/TrEMBL
    Q8C237
    Related
    ENSMUSP00000084591.3, ENSMUST00000087333.9
    Conserved Domains (1) summary
    pfam14808
    Location:10 → 272
    TMEM164; TMEM164 family

RNA

  1. NR_152447.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL731674, AL731678

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    141463343..141626490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528784.4 → XP_006528847.1  transmembrane protein 164 isoform X6

    See identical proteins and their annotated locations for XP_006528847.1

    UniProtKB/TrEMBL
    A2AH99
    Conserved Domains (1) summary
    pfam14808
    Location:1 → 124
    TMEM164; TMEM164 family

  2. XM_030251291.2 → XP_030107151.1  transmembrane protein 164 isoform X1

    Conserved Domains (1) summary
    pfam14808
    Location:10 → 233
    TMEM164; TMEM164 family

  3. XM_006528781.3 → XP_006528844.1  transmembrane protein 164 isoform X3

    Conserved Domains (1) summary
    pfam14808
    Location:10 → 168
    TMEM164; TMEM164 family

  4. XM_030251292.2 → XP_030107152.1  transmembrane protein 164 isoform X5

    Conserved Domains (1) summary
    pfam14808
    Location:2 → 127
    TMEM164; TMEM164 family

  5. XM_006528780.3 → XP_006528843.1  transmembrane protein 164 isoform X2

    Conserved Domains (1) summary
    pfam14808
    Location:10 → 229
    TMEM164; TMEM164 family

  6. XM_006528779.3 → XP_006528842.1  transmembrane protein 164 isoform X1

    See identical proteins and their annotated locations for XP_006528842.1

    Conserved Domains (1) summary
    pfam14808
    Location:10 → 233
    TMEM164; TMEM164 family

  7. XM_011247804.3 → XP_011246106.1  transmembrane protein 164 isoform X4

    Conserved Domains (1) summary
    pfam14808
    Location:23 → 166
    TMEM164; TMEM164 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHN7.1 GenPept UniProtKB/Swiss-Prot:Q6PHN7

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