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Surf1 surfeit gene 1 [ Mus musculus (house mouse) ]

Gene ID: 20930, updated on 2-Nov-2024

Summary

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Official Symbol
Surf1provided by MGI
Official Full Name
surfeit gene 1provided by MGI
Primary source
MGI:MGI:98443
See related
Ensembl:ENSMUSG00000015790 AllianceGenome:MGI:98443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Surf-1; 0610010F23Rik
Summary
Enables cytochrome-c oxidase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in brain; embryo; and skeletal muscle. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4K; Leigh disease; and mitochondrial complex IV deficiency nuclear type 1. Orthologous to human SURF1 (SURF1 cytochrome c oxidase assembly factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 27.0), cerebellum adult (RPKM 26.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Surf1 in Genome Data Viewer
Location:
2 A3; 2 19.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26803390..26806667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26913378..26916610, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A Neighboring gene predicted gene, 24134 Neighboring gene predicted gene, 57689 Neighboring gene surfeit gene 2 Neighboring gene surfeit gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene REX4, 3'-5' exonuclease Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26819876-26820059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Deepa SS, et al. Aging Cell, 2018 Aug. PMID 29696791, Free PMC Article
  2. Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration. Solano Fonseca R, et al. Elife, 2021 Sep 2. PMID 34473622, Free PMC Article
  3. Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts. Pharaoh G, et al. Redox Biol, 2016 Aug. PMID 27208630, Free PMC Article
  4. Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Pulliam DA, et al. Biochem J, 2014 Sep 1. PMID 24911525, Free PMC Article
  5. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. Deepa SS, et al. FASEB J, 2013 Apr. PMID 23241310

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Many proteins and metabolites are downregulated in Surf1(-/-) adipose tissue and reversed by Dietary restriction (DR), while in brain, most metabolites that changed were elevated in Surf1(-/-) mice.
    Title: Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
  2. studies support the view that COX assembly is much more dependent on SURF1 in humans than in mice.
    Title: Tissue- and species-specific differences in cytochrome c oxidase assembly induced by SURF1 defects.
  3. Fibroblasts from Surf1(-/-) mice are significantly more resistant to cell death caused by oxidative stress induced by paraquat or tert-Butyl hydroperoxide compared to cells from wild-type mice. In contrast, Surf1(-/-) fibroblasts show no difference in sensitivity to hydrogen peroxide stress
    Title: Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts.
  4. These findings suggest that Surf1 deficiency-induced metabolic alterations may have positive effects on brain function.
    Title: Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice.
  5. The expression of peroxisome proliferator-activated receptor gamma-coactivator 1-alpha (PGC-1alpha) mRNA and protein was up-regulated in white adipose tissue from Surf1-/- mice, and the expression of PGC-1alpha target genes
    Title: Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity.
  6. Compared to wild type (WT) preparations Surf1 knockout preparations had a higher baseline respiratory frequency and abnormal responses to hypoxia and hypercapnia that involved both respiratory frequency and motor nerve discharge pattern.
    Title: Hypoxic and hypercapnic challenges unveil respiratory vulnerability of Surf1 knockout mice, an animal model of Leigh syndrome.
  7. murine Surf1 protein (Surf1p) has a function specifically related to cytochrome c oxidase
    Title: Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice.
  8. Prolonged lifespan and complete protection from Ca(2+)-dependent neurotoxicity induced by kainic acid in Surf-1 knockout mice.
    Title: Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
surfeit locus protein 1
NP_001258653.2
NP_038705.2
XP_006497884.1
XP_006497886.1
XP_006497887.1
XP_006497888.1
XP_006497889.1
XP_030104977.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271724.1 → NP_001258653.2  surfeit locus protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. An in-frame AUG is located 32 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AK002469, AL773563, BE955575
    UniProtKB/TrEMBL
    Q3U3J6
    Conserved Domains (1) summary
    pfam02104
    Location:74 → 277
    SURF1; SURF1 family

  2. NM_013677.2 → NP_038705.2  surfeit locus protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038705.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). An in-frame AUG is located 32 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AK002469, AL773563, BE955575, BU697260, CB524655
    Consensus CDS
    CCDS50543.1
    UniProtKB/Swiss-Prot
    P09925, Q99KB4, Q9DCU5
    UniProtKB/TrEMBL
    Q3U3J6
    Related
    ENSMUSP00000015934.8, ENSMUST00000015934.13
    Conserved Domains (1) summary
    cd06662
    Location:81 → 294
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

RNA

  1. NR_073420.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK002469, AL773563, BE955575, BY268659, CB524655
    Related
    ENSMUST00000167661.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26803390..26806667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497823.5 → XP_006497886.1  surfeit locus protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0A6YVR9
    Conserved Domains (1) summary
    cd06662
    Location:45 → 258
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

  2. XM_006497824.4 → XP_006497887.1  surfeit locus protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006497887.1

    UniProtKB/TrEMBL
    A0A0A6YVR9, I6L9E0
    Conserved Domains (1) summary
    cd06662
    Location:38 → 251
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

  3. XM_006497826.5 → XP_006497889.1  surfeit locus protein 1 isoform X4

    Conserved Domains (1) summary
    cd06662
    Location:113 → 208
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

  4. XM_030249117.2 → XP_030104977.1  surfeit locus protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A6YVR9, I6L9E0
    Conserved Domains (1) summary
    cd06662
    Location:38 → 251
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

  5. XM_006497821.5 → XP_006497884.1  surfeit locus protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVR9
    Conserved Domains (1) summary
    cd06662
    Location:69 → 282
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

  6. XM_006497825.4 → XP_006497888.1  surfeit locus protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006497888.1

    UniProtKB/TrEMBL
    A0A0A6YVR9, I6L9E0
    Related
    ENSMUSP00000141238.2, ENSMUST00000147110.8
    Conserved Domains (1) summary
    cd06662
    Location:38 → 251
    SURF1; SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring ...

RNA

  1. XR_374066.5 RNA Sequence

  2. XR_003951791.2 RNA Sequence

  3. XR_004939256.1 RNA Sequence

    Related
    ENSMUST00000183520.8

  4. XR_003951793.1 RNA Sequence

  5. XR_004939255.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09925.3 GenPept UniProtKB/Swiss-Prot:P09925

Gene LinkOut

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