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Sts steroid sulfatase [ Mus musculus (house mouse) ]

Gene ID: 20905, updated on 2-Nov-2024

Summary

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Official Symbol
Stsprovided by MGI
Official Full Name
steroid sulfataseprovided by MGI
Primary source
MGI:MGI:98438
See related
AllianceGenome:MGI:98438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ArsC
Summary
Predicted to enable arylsulfatase activity and steryl-sulfatase activity. Predicted to be involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Is expressed in several structures, including central nervous system; sensory organ; skeleton; skin; and spleen. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human all
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Genomic context

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See Sts in Genome Data Viewer
Location:
X F5; X
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168856332..169015037, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene midline 1 Neighboring gene STARR-seq mESC enhancer starr_48290 Neighboring gene predicted gene 15247 Neighboring gene erythroid differentiation regulator 1 x Neighboring gene RIKEN cDNA 2510022D24 gene Neighboring gene neuroligin 4-like Neighboring gene A-kinase anchoring protein 17A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000086.8 Chromosome X Reference GRCm39 C57BL/6J

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of murine arylsulfatase C and steroid sulfatase. Keinanen BM, et al. Genetics, 1983 Sep. PMID 6225698, Free PMC Article
  2. Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice. Gartler SM, et al. Genetics, 1983 Jan. PMID 6573292, Free PMC Article
  3. Variation in regulation of steroid sulphatase locus in mammals. Crocker M, et al. Nature, 1983 Jun 23-29. PMID 6574326
  4. Dosage of the Sts gene in the mouse. Keitges E, et al. Am J Hum Genet, 1986 Oct. PMID 3464202, Free PMC Article
  5. Identification of an autosomal locus affecting steroid sulfatase activity among inbred strains of mice. Erickson RP, et al. Genetics, 1983 Sep. PMID 6578171, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results revealed an essential role of the adipose STS in energy homeostasis in sex- and sex hormone-dependent manner. Adipose expression of Sts was induced in the high-fat diet (HFD) and ob/ob models of obesity and type 2 diabetes.
    Title: Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis.
  2. Overexpression of STS in the liver improved metabolic functions in mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
    Title: Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
  3. These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system.
    Title: Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.
  4. steroid sulfatase may influence core and associated ADHD behavioural endophenotypes via both developmental and ongoing mechanisms, and that the 39,X(Y*)O model may represent a useful tool for elucidating the neurobiological basis of these endophenotypes.
    Title: Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.
  5. analysis of brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene
    Title: Brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene.
  6. Our data suggest that variation within STS may be particularly associated with the inattentive subtype of ADHD
    Title: Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables steryl-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables steryl-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
steryl-sulfatase
Names
ASC
arylsulfatase C
steryl-sulfate sulfohydrolase
NP_033319.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009293.1 → NP_033319.1  steryl-sulfatase precursor

    See identical proteins and their annotated locations for NP_033319.1

    Status: PROVISIONAL

    Source sequence(s)
    U37545
    UniProtKB/Swiss-Prot
    P50427
    Conserved Domains (2) summary
    COG3119
    Location:36 → 530
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:36 → 535
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    168856332..169015037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50427.1 GenPept UniProtKB/Swiss-Prot:P50427

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous