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Zfp280c zinc finger protein 280C [ Mus musculus (house mouse) ]

Gene ID: 208968, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp280cprovided by MGI
Official Full Name
zinc finger protein 280Cprovided by MGI
Primary source
MGI:MGI:2387585
See related
Ensembl:ENSMUSG00000036916 AllianceGenome:MGI:2387585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Suhw3; Zfp633; Znf280c; mKIAA1584
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in brain; dorsal root ganglion; early conceptus; and spinal cord. Orthologous to human ZNF280C (zinc finger protein 280C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 8.8), CNS E14 (RPKM 8.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp280c in Genome Data Viewer
Location:
X A5; X 25.68 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47630503..47683599, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48541626..48594648, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene solute carrier family 25 (mitochondrial carrier, brain), member 14 Neighboring gene G-protein coupled receptor 119

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci. Ying Y, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35605119, Free PMC Article
  2. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38010

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 280C
Names
suppressor of hairy wing homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166648.2 → NP_001160120.1  zinc finger protein 280C isoform 1

    See identical proteins and their annotated locations for NP_001160120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI481209, AK141491, AL669901
    Consensus CDS
    CCDS30111.1
    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Related
    ENSMUSP00000086288.5, ENSMUST00000088898.11
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  2. NM_001166649.2 → NP_001160121.1  zinc finger protein 280C isoform 2

    See identical proteins and their annotated locations for NP_001160121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR and uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI481209, AL669901
    Consensus CDS
    CCDS53064.1
    UniProtKB/Swiss-Prot
    Q6P3Y5
    Related
    ENSMUSP00000072138.6, ENSMUST00000072292.12
    Conserved Domains (2) summary
    sd00017
    Location:353 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:47 → 218
    DUF4195; Domain of unknown function (DUF4195)

  3. NM_001166650.2 → NP_001160122.1  zinc finger protein 280C isoform 3

    See identical proteins and their annotated locations for NP_001160122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks part of the 5' UTR and an alternate exon in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI481209, AK141491, AL669901
    Consensus CDS
    CCDS53065.1
    UniProtKB/Swiss-Prot
    Q6P3Y5
    Related
    ENSMUSP00000110590.3, ENSMUST00000114940.9
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  4. NM_001358792.1 → NP_001345721.1  zinc finger protein 280C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AI481209, AL669901
    Conserved Domains (2) summary
    sd00017
    Location:339 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:33 → 208
    DUF4195; Domain of unknown function (DUF4195)

  5. NM_153532.4 → NP_705760.2  zinc finger protein 280C isoform 1

    See identical proteins and their annotated locations for NP_705760.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI481209, AK141491, AL669901
    Consensus CDS
    CCDS30111.1
    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Related
    ENSMUSP00000075933.7, ENSMUST00000076635.13
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47630503..47683599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161884.1 → XP_036017777.1  zinc finger protein 280C isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:339 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:33 → 208
    DUF4195; Domain of unknown function (DUF4195)

  2. XM_036161882.1 → XP_036017775.1  zinc finger protein 280C isoform X1

    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  3. XM_036161885.1 → XP_036017778.1  zinc finger protein 280C isoform X4

    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  4. XM_036161881.1 → XP_036017774.1  zinc finger protein 280C isoform X1

    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  5. XM_006541464.5 → XP_006541527.1  zinc finger protein 280C isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:339 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:33 → 208
    DUF4195; Domain of unknown function (DUF4195)

  6. XM_006541458.5 → XP_006541521.1  zinc finger protein 280C isoform X1

    See identical proteins and their annotated locations for XP_006541521.1

    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  7. XM_036161883.1 → XP_036017776.1  zinc finger protein 280C isoform X1

    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  8. XM_030251282.2 → XP_030107142.1  zinc finger protein 280C isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:339 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:33 → 208
    DUF4195; Domain of unknown function (DUF4195)

  9. XM_030251281.2 → XP_030107141.1  zinc finger protein 280C isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:353 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:47 → 218
    DUF4195; Domain of unknown function (DUF4195)

  10. XM_030251283.2 → XP_030107143.1  zinc finger protein 280C isoform X4

    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  11. XM_006541459.5 → XP_006541522.1  zinc finger protein 280C isoform X1

    See identical proteins and their annotated locations for XP_006541522.1

    UniProtKB/Swiss-Prot
    B1AU28, B1AU29, Q6P3Y5, Q6ZPM2, Q8K145
    Conserved Domains (2) summary
    sd00017
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:56 → 231
    DUF4195; Domain of unknown function (DUF4195)

  12. XM_036161887.1 → XP_036017780.1  zinc finger protein 280C isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:353 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:47 → 222
    DUF4195; Domain of unknown function (DUF4195)

  13. XM_030251284.2 → XP_030107144.1  zinc finger protein 280C isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:353 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:47 → 222
    DUF4195; Domain of unknown function (DUF4195)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3Y5.1 GenPept UniProtKB/Swiss-Prot:Q6P3Y5

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