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Nek11 NIMA (never in mitosis gene a)-related expressed kinase 11 [ Mus musculus (house mouse) ]

Gene ID: 208583, updated on 28-Oct-2024

Summary

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Official Symbol
Nek11provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 11provided by MGI
Primary source
MGI:MGI:2442276
See related
Ensembl:ENSMUSG00000035032 AllianceGenome:MGI:2442276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932416N14Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitotic intra-S DNA damage checkpoint signaling; protein phosphorylation; and regulation of mitotic cell cycle phase transition. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cartilage; central nervous system; genitourinary system; and respiratory system. Orthologous to human NEK11 (NIMA related kinase 11). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 3.4), lung adult (RPKM 0.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Nek11 in Genome Data Viewer
Location:
9 F1; 9 56.61 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (105039355..105272723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105162156..105395524, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5099 Neighboring gene nudix hydrolase 16 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E895 Neighboring gene STARR-positive B cell enhancer ABC_E3856 Neighboring gene STARR-positive B cell enhancer ABC_E5100 Neighboring gene asteroid homolog 1 Neighboring gene ATPase, Ca++-sequestering Neighboring gene STARR-positive B cell enhancer mm9_chr9:105398187-105398487 Neighboring gene predicted gene, 40564 Neighboring gene STARR-seq mESC enhancer starr_25124 Neighboring gene STARR-seq mESC enhancer starr_25126 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek11
Names
NIMA-related kinase 11
never in mitosis A-related kinase 11
nimA-related protein kinase 11
NP_766049.2
XP_006511742.1
XP_006511743.1
XP_006511745.1
XP_006511748.1
XP_006511749.1
XP_017168748.1
XP_030100034.1
XP_036010662.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172461.4 → NP_766049.2  serine/threonine-protein kinase Nek11

    See identical proteins and their annotated locations for NP_766049.2

    Status: VALIDATED

    Source sequence(s)
    AC113016, AC161250
    Consensus CDS
    CCDS23464.1
    UniProtKB/Swiss-Prot
    E9QNC3, Q8BLS6, Q8BW62, Q8C0Q4
    UniProtKB/TrEMBL
    Q0VDN9
    Related
    ENSMUSP00000038611.5, ENSMUST00000038648.11
    Conserved Domains (1) summary
    cd08222
    Location:29 → 288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    105039355..105272723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154769.1 → XP_036010662.1  serine/threonine-protein kinase Nek11 isoform X7

    Conserved Domains (2) summary
    COG4913
    Location:63 → 191
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    cl21453
    Location:1 → 63
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030244174.2 → XP_030100034.1  serine/threonine-protein kinase Nek11 isoform X7

    Conserved Domains (2) summary
    COG4913
    Location:63 → 191
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    cl21453
    Location:1 → 63
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006511679.5 → XP_006511742.1  serine/threonine-protein kinase Nek11 isoform X1

    See identical proteins and their annotated locations for XP_006511742.1

    UniProtKB/Swiss-Prot
    E9QNC3, Q8BLS6, Q8BW62, Q8C0Q4
    UniProtKB/TrEMBL
    Q0VDN9
    Conserved Domains (1) summary
    cd08222
    Location:29 → 288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  4. XM_006511682.4 → XP_006511745.1  serine/threonine-protein kinase Nek11 isoform X3

    UniProtKB/TrEMBL
    Q0VDN9
    Conserved Domains (1) summary
    cl21453
    Location:1 → 189
    PKc_like; Protein Kinases, catalytic domain

  5. XM_017313259.2 → XP_017168748.1  serine/threonine-protein kinase Nek11 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 139
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006511686.4 → XP_006511749.1  serine/threonine-protein kinase Nek11 isoform X6

    Conserved Domains (2) summary
    COG4913
    Location:75 → 203
    COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    cl21453
    Location:5 → 75
    PKc_like; Protein Kinases, catalytic domain

  7. XM_006511680.1 → XP_006511743.1  serine/threonine-protein kinase Nek11 isoform X2

    UniProtKB/TrEMBL
    Q0VDN9
    Conserved Domains (1) summary
    cd08222
    Location:29 → 288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

  8. XM_006511685.2 → XP_006511748.1  serine/threonine-protein kinase Nek11 isoform X5

    UniProtKB/TrEMBL
    D3Z1E7
    Related
    ENSMUSP00000116864.2, ENSMUST00000140851.3
    Conserved Domains (1) summary
    cd08222
    Location:29 → 288
    STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

RNA

  1. XR_003947831.1 RNA Sequence

  2. XR_379760.1 RNA Sequence

  3. XR_379761.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0Q4.2 GenPept UniProtKB/Swiss-Prot:Q8C0Q4

Gene LinkOut

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